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Synthetic leptin peptide fragment. Restricts weight gain and reduces food intake in female mice lacking endogenously circulating active leptin.
(Modifications: Ser-15 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Grasso et al (1997) In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140. Endocrinology 138 1413 PMID: 9075696
Grasso et al (1999) Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes 48 2204 PMID: 10535455
Rozhavskaya et al (2000) Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis and thermoregulation. Endocrinology 141 2501 PMID: 10875251
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Keywords: LEP (116-130) (mouse), LEP (116-130) (mouse) supplier, Synthetic, leptin, peptide, fragment, Receptors, adipokines, Leptin, 2985, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.