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Biological Activity for Lenalidomide 4'-PEG3-amine
Lenalidomide 4'-PEG3-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for Lenalidomide 4'-PEG3-amine
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for Lenalidomide 4'-PEG3-amine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Lenalidomide 4'-PEG3-amine
References for Lenalidomide 4'-PEG3-amine
References are publications that support the biological activity of the product.
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Keywords: Lenalidomide 4'-PEG3-amine, Lenalidomide 4'-PEG3-amine supplier, PROTAC, cereblon, E3, ubiquitin, ligase, PEG3, linker, conjugate, polyethylene, glycol, terminal, amine, building, blocks, components, Cereblon, Ligands, Plus, Linkers, 7076, Tocris Bioscience
1 Citation for Lenalidomide 4'-PEG3-amine
Citations are publications that use Tocris products. Selected citations for Lenalidomide 4'-PEG3-amine include:
Jason W et al (2019) Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metab 29 141-155.e9 PMID: 30174305
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Literature in this Area
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Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia