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Submit ReviewLDN 27219
Description: Transglutaminase 2 (TG2) inhibitor; reversible
Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]acetic acid hydrazide
Purity: ≥99% (HPLC)
Biological Activity for LDN 27219
LDN 27219 is a transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.
Compound Libraries for LDN 27219
LDN 27219 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LDN 27219
| M. Wt | 408.5 |
| Formula | C20H16N4O2S2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 312946-37-5 |
| PubChem ID | 1150683 |
| InChI Key | WLBUICQBNZXIDJ-UHFFFAOYSA-N |
| Smiles | O=C(NN)CSC(N1C2=CC=CC=C2)=NC3=C(C(C4=CC=CC=C4)=CS3)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LDN 27219
References for LDN 27219
References are publications that support the biological activity of the product.
Case and Stein (2007) Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 46 1106 PMID: 17240993
Prime et al (2012) Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J.Med.Chem. 55 1021 PMID: 22224594
Duval et al (2005) Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 15 1885 PMID: 15780627
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Keywords: LDN 27219, LDN 27219 supplier, LDN27219, transglutaminases, 2, TG2, TGase, tissue, tTG, inhibits, inhibitors, reversible, Other, Transferases, 4602, Tocris Bioscience
2 Citations for LDN 27219
Citations are publications that use Tocris products. Selected citations for LDN 27219 include:
Yeo et al (2016) Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Mediators Inflamm 5 PMID: 26956429
Harry T et al (2022) Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. J Clin Invest 132 PMID: 35499073
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