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Submit ReviewLDN 209929 dihydrochloride
Description: Potent and selective haspin inhibitor
Chemical Name: 3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for LDN 209929 dihydrochloride
LDN 209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50 = 55 nM). Displays 180-fold selectivity over DYRK2.
Technical Data for LDN 209929 dihydrochloride
| M. Wt | 405.77 |
| Formula | C17H17ClN2OS.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1784281-97-5 |
| PubChem ID | 90488975 |
| InChI Key | WOCCOXNODBCCGK-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N=C(C=CC(OC)=C3)C3=C2SCCCN)C2=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LDN 209929 dihydrochloride
References for LDN 209929 dihydrochloride
References are publications that support the biological activity of the product.
Cuny et al (2010) Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg.Med.Chem.Lett. 20 3491 PMID: 20836251
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Citations for LDN 209929 dihydrochloride
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