LDN 209929 dihydrochloride
Potent and selective haspin kinase inhibitor (IC50 = 55 nM). Displays 180-fold selectivity over DYRK2.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 405.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.46 mL||12.32 mL||24.64 mL|
|5 mM||0.49 mL||2.46 mL||4.93 mL|
|10 mM||0.25 mL||1.23 mL||2.46 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cuny et al (2010) Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg.Med.Chem.Lett. 20 3491 PMID: 20836251
If you know of a relevant reference for LDN 209929 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: LDN 209929 dihydrochloride, supplier, LDN209929, dihydrochloride, haploid, germ, cells, specific, nuclear, protein, haspin, kinases, gsg2, mitosis, potent, selective, Haspin, Tocris Bioscience
Citations for LDN 209929 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for LDN 209929 dihydrochloride. Do you know of a great paper that uses LDN 209929 dihydrochloride from Tocris? If so please let us know.
Literature in this Area
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.