LDN 209929 dihydrochloride

Pricing Availability   Qty
Description: Potent and selective haspin inhibitor
Chemical Name: 3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for LDN 209929 dihydrochloride

LDN 209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50 = 55 nM). Displays 180-fold selectivity over DYRK2.

Technical Data for LDN 209929 dihydrochloride

M. Wt 405.77
Formula C17H17ClN2OS.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1784281-97-5
PubChem ID 90488975
InChI Key WOCCOXNODBCCGK-UHFFFAOYSA-N
Smiles ClC1=CC=C(N=C(C=CC(OC)=C3)C3=C2SCCCN)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LDN 209929 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 40.58 100
DMSO 40.58 100

Preparing Stock Solutions for LDN 209929 dihydrochloride

The following data is based on the product molecular weight 405.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for LDN 209929 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for LDN 209929 dihydrochloride

References are publications that support the biological activity of the product.

Cuny et al (2010) Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg.Med.Chem.Lett. 20 3491 PMID: 20836251


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Citations for LDN 209929 dihydrochloride

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Literature in this Area

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Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.