LDN 209929 dihydrochloride

Pricing Availability   Qty
Description: Potent and selective haspin inhibitor
Chemical Name: 3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for LDN 209929 dihydrochloride

LDN 209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50 = 55 nM). Displays 180-fold selectivity over DYRK2.

Technical Data for LDN 209929 dihydrochloride

M. Wt 405.77
Formula C17H17ClN2OS.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1784281-97-5
PubChem ID 90488975
Smiles ClC1=CC=C(N=C(C=CC(OC)=C3)C3=C2SCCCN)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LDN 209929 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 40.58 100
DMSO 40.58 100

Preparing Stock Solutions for LDN 209929 dihydrochloride

The following data is based on the product molecular weight 405.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for LDN 209929 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for LDN 209929 dihydrochloride

References are publications that support the biological activity of the product.

Cuny et al (2010) Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg.Med.Chem.Lett. 20 3491 PMID: 20836251

If you know of a relevant reference for LDN 209929 dihydrochloride, please let us know.

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Citations for LDN 209929 dihydrochloride

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