You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Laulimalide
Laulimalide is a microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.
Technical Data for Laulimalide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Laulimalide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Laulimalide
The following data is based on the product molecular weight 514.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.72 mL||48.58 mL||97.15 mL|
|1 mM||1.94 mL||9.72 mL||19.43 mL|
|2 mM||0.97 mL||4.86 mL||9.72 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
References for Laulimalide
References are publications that support the biological activity of the product.
Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41 9109 PMID: 12119025
Bennett et al (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 11 3045 PMID: 22871740
Bennett et al (2010) Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 17 725 PMID: 20659685
If you know of a relevant reference for Laulimalide, please let us know.
Keywords: Laulimalide, Laulimalide supplier, Laulimalide, Fijianolide, B, microtubule, stabilizers, stabilizing, agents, cell, proliferation, inhibitors, Microtubules, 4007, Tocris Bioscience
Citations for Laulimalide
Citations are publications that use Tocris products.
Currently there are no citations for Laulimalide. Do you know of a great paper that uses Laulimalide from Tocris? Please let us know.
Reviews for Laulimalide
There are currently no reviews for this product. Be the first to review Laulimalide and earn rewards!
Have you used Laulimalide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.