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Discontinued ProductLaulimalide (Cat. No. 4007) has been withdrawn from sale for commercial reasons.
Biological Activity for Laulimalide
Laulimalide is a microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.
Technical Data for Laulimalide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Laulimalide
References are publications that support the biological activity of the product.
Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41 9109 PMID: 12119025
Bennett et al (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 11 3045 PMID: 22871740
Bennett et al (2010) Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 17 725 PMID: 20659685
Keywords: Laulimalide, Laulimalide supplier, Laulimalide, Fijianolide, B, microtubule, stabilizers, stabilizing, agents, cell, proliferation, inhibitors, Microtubules, 4007, Tocris Bioscience
Citations for Laulimalide
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Currently there are no citations for Laulimalide.
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
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- DNA Damage Repair
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