Latanoprost

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Cat.No. 4757 - Latanoprost | C26H40O5 | CAS No. 130209-82-4
Description: FP prostaglandin receptor agonist; also exhibits agonist activity at EP1 and EP3 receptors
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptanoic acid 1-methylethyl ester
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

FP prostaglandin receptor agonist; displays greater selectivity than prostanglandin F2α (Cat. No. 4214). Exhibits agonist activity at EP1 and EP3 receptors, but little-to-no effect at EP2, DP, IP and TP prostanoid receptors.

Technical Data

M. Wt 432.59
Formula C26H40O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 130209-82-4
PubChem ID 5311221
InChI Key GGXICVAJURFBLW-CEYXHVGTSA-N
Smiles O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.63 50
ethanol 21.63 50

Preparing Stock Solutions

The following data is based on the product molecular weight 432.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.62 mL 23.12 mL 46.23 mL
2.5 mM 0.92 mL 4.62 mL 9.25 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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References

References are publications that support the biological activity of the product.

Stjernschantz (2001) From PGF2α-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. Invest.Ophthalmol.Vis.Sci. 42 1134 PMID: 11328719


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Citations for Latanoprost

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