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FP prostaglandin receptor agonist; displays greater selectivity than prostanglandin F2α (Cat. No. 4214). Exhibits agonist activity at EP1 and EP3 receptors, but little-to-no effect at EP2, DP, IP and TP prostanoid receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 432.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.62 mL||23.12 mL||46.23 mL|
|2.5 mM||0.92 mL||4.62 mL||9.25 mL|
|5 mM||0.46 mL||2.31 mL||4.62 mL|
|25 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the biological activity of the product.
Stjernschantz (2001) From PGF2α-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. Invest.Ophthalmol.Vis.Sci. 42 1134 PMID: 11328719
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Keywords: Latanoprost, Latanoprost supplier, Pfizer, latanoprost, prostaglandins, receptors, FP, agonists, EP1, EP3, Prostanoid, Receptors, 4757, Tocris Bioscience
Citations for Latanoprost
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.