Lalistat 2

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Cat.No. 6099 - Lalistat 2 | C13H20N4O2S | CAS No. 1234569-09-5
Description: Selective LAL inhibitor
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective Lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Technical Data

M. Wt 296.39
Formula C13H20N4O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1234569-09-5
PubChem ID 46867138
InChI Key PNYYVHOTXOEBEV-UHFFFAOYSA-N
Smiles O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.64 100
ethanol 29.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 296.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Hamilton et al (2012) A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 413 1207 PMID: 22483793

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099


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Citations for Lalistat 2

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Literature in this Area

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