Lalistat 2

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Description: Selective LAL inhibitor
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for Lalistat 2

Lalistat 2 is a selective lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Compound Libraries for Lalistat 2

Lalistat 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Lalistat 2

M. Wt 296.39
Formula C13H20N4O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1234569-09-5
PubChem ID 46867138
InChI Key PNYYVHOTXOEBEV-UHFFFAOYSA-N
Smiles O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lalistat 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.64 100
ethanol 29.64 100

Preparing Stock Solutions for Lalistat 2

The following data is based on the product molecular weight 296.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for Lalistat 2

References are publications that support the biological activity of the product.

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Hamilton et al (2012) A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 413 1207 PMID: 22483793

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099


If you know of a relevant reference for Lalistat 2, please let us know.

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2 Citations for Lalistat 2

Citations are publications that use Tocris products. Selected citations for Lalistat 2 include:

Debaditya et al (2020) Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. J Biol Chem 295 18284-18300 PMID: 33109611

Debaditya et al (2020) Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. J Biol Chem 295 18284-18300 PMID: 33453834


Do you know of a great paper that uses Lalistat 2 from Tocris? Please let us know.

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