Lalistat 2

Pricing Availability Delivery Time Qty
Cat.No. 6099 - Lalistat 2 | C13H20N4O2S | CAS No. 1234569-09-5
Description: Selective lysosomal acid lipase inhibitor
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective Lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Technical Data

M. Wt 296.39
Formula C13H20N4O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1234569-09-5
PubChem ID 46867138
InChI Key PNYYVHOTXOEBEV-UHFFFAOYSA-N
Smiles O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.64 100
ethanol 29.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 296.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Hamilton et al (2012) A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 413 1207 PMID: 2483793

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099


If you know of a relevant reference for Lalistat 2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Hydrolase Inhibitors

Keywords: Lalistat 2, supplier, Lalistat2, selective, lysosomal, acid, lipase, inhibitors, inhibits, Niemann-Pick, type, C, (NPC), disease, is, a, lysosomal, storage, disorder, Other, Hydrolases, Other, Hydrolases, Tocris Bioscience

Citations for Lalistat 2

Citations are publications that use Tocris products.

Currently there are no citations for Lalistat 2. Do you know of a great paper that uses Lalistat 2 from Tocris? If so please let us know.

Lalistat 2 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Lalistat 2?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells