Lalistat 1

Pricing Availability   Qty
Description: Potent and selective LAL inhibitor
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Lalistat 1

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

Compound Libraries for Lalistat 1

Lalistat 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Lalistat 1

M. Wt 298.36
Formula C12H18N4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 501104-16-1
PubChem ID 648404

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lalistat 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.84 100
ethanol 29.84 100

Preparing Stock Solutions for Lalistat 1

The following data is based on the product molecular weight 298.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for Lalistat 1

References are publications that support the biological activity of the product.

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Ouimet et al (2011) Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 13 655 PMID: 21641547

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099

If you know of a relevant reference for Lalistat 1, please let us know.

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1 Citation for Lalistat 1

Citations are publications that use Tocris products. Selected citations for Lalistat 1 include:

Wu et al (2019) Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes. Hepatol Commun 3 406 PMID: 30859152

Do you know of a great paper that uses Lalistat 1 from Tocris? Please let us know.

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Literature in this Area

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