L002

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Cat.No. 5045 - L002 | C15H15NO5S | CAS No. 321695-57-2
Description: p300 inhibitor
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.

Compound Libraries

L002 is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 321.35
Formula C15H15NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 321695-57-2
PubChem ID 2221149
InChI Key VEWFTYOFWIXCIO-UHFFFAOYSA-N
Smiles O=C(C(C)=C2)C(C)=C\C2=N/OS(C1=CC=C(OC)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.13 100
ethanol 3.21 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 321.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References

References are publications that support the biological activity of the product.

Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610 PMID: 23625935


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View Related Products by Product Action

View all Histone Acetyltransferase Inhibitors

Keywords: L002, L002 supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Histone, Acetyltransferases, Post-translational, Modifications, 5045, Tocris Bioscience

Citations for L002

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Literature in this Area

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Epigenetics Scientific Review

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