L002

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Cat.No. 5045 - L002 | C15H15NO5S | CAS No. 321695-57-2
Description: p300 inhibitor
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.

Compound Libraries

L002 is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 321.35
Formula C15H15NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 321695-57-2
PubChem ID 2221149
InChI Key VEWFTYOFWIXCIO-UHFFFAOYSA-N
Smiles O=C(C(C)=C2)C(C)=C\C2=N/OS(C1=CC=C(OC)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.13 100
ethanol 3.21 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 321.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610 PMID: 23625935


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View Related Products by Product Action

View all Histone Acetyltransferase Inhibitors

Keywords: L002, supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Histone, Acetyltransferases, Post-translational, Modifications, Histone, Acetyltransferases, Tocris Bioscience

Citations for L002

Citations are publications that use Tocris products.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases

Pathways for L002

Protocols

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