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Cat.No. 5045 - L002 | C15H15NO5S | CAS No. 321695-57-2
Description: p300 inhibitor
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for L002

L002 is a p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.

Technical Data for L002

M. Wt 321.35
Formula C15H15NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 321695-57-2
PubChem ID 2221149
Smiles O=C(C(C)=C2)C(C)=C\C2=N/OS(C1=CC=C(OC)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L002

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.13 100
ethanol 3.21 10 with gentle warming

Preparing Stock Solutions for L002

The following data is based on the product molecular weight 321.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for L002

References are publications that support the biological activity of the product.

Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610 PMID: 23625935

If you know of a relevant reference for L002, please let us know.

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Keywords: L002, L002 supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Histone, Acetyltransferases, Post-translational, Modifications, 5045, Tocris Bioscience

Citations for L002

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Literature in this Area

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