L002

Discontinued Product

L002 (Cat. No. 5045) has been withdrawn from sale for commercial reasons.
Cat.No. 5045 - L002 | C15H15NO5S | CAS No. 321695-57-2
Description: p300 inhibitor
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for L002

L002 is a p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.

Technical Data for L002

M. Wt 321.35
Formula C15H15NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 321695-57-2
PubChem ID 2221149
InChI Key VEWFTYOFWIXCIO-UHFFFAOYSA-N
Smiles O=C(C(C)=C2)C(C)=C\C2=N/OS(C1=CC=C(OC)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for L002

References are publications that support the biological activity of the product.

Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610 PMID: 23625935

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Keywords: L002, L002 supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Histone, Acetyltransferases, Post-translational, Modifications, 5045, Tocris Bioscience

Citations for L002

Citations are publications that use Tocris products.

Currently there are no citations for L002.

Reviews for L002

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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