L-(-)-threo-3-Hydroxyaspartic acid

Pricing Availability   Qty
Description: Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names: L-threo-β-Hydroxyaspartic acid
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for L-(-)-threo-3-Hydroxyaspartic acid

L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT1, EAAT2 and EAAT3, Ki values are 11, 19, and 14 μM, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values are 3.6, 3.8 and 3.2 μM for human EAAT1, EAAT2 and EAAT3, respectively.

Technical Data for L-(-)-threo-3-Hydroxyaspartic acid

M. Wt 149.1
Formula C4H7NO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 7298-99-9
PubChem ID 443239
Smiles [H][C@@]([C@]([H])(O)C(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-(-)-threo-3-Hydroxyaspartic acid

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 100

Preparing Stock Solutions for L-(-)-threo-3-Hydroxyaspartic acid

The following data is based on the product molecular weight 149.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.71 mL 33.53 mL 67.07 mL
5 mM 1.34 mL 6.71 mL 13.41 mL
10 mM 0.67 mL 3.35 mL 6.71 mL
50 mM 0.13 mL 0.67 mL 1.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for L-(-)-threo-3-Hydroxyaspartic acid

Certificate of Analysis / Product Datasheet
Select another batch:

References for L-(-)-threo-3-Hydroxyaspartic acid

References are publications that support the biological activity of the product.

Johnston et al (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 34 241 PMID: 7452241

McBean and Roberts (1985) Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 44 247 PMID: 2856883

Nakamura et al (1993) (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833 PMID: 7901789

Jensen and Bräuner-Osborne (2004) Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem.Pharmacol. 67 2115 PMID: 15135308

If you know of a relevant reference for L-(-)-threo-3-Hydroxyaspartic acid, please let us know.

View Related Products by Product Action

View all Glutamate Transporter Inhibitors

Keywords: L-(-)-threo-3-Hydroxyaspartic acid, L-(-)-threo-3-Hydroxyaspartic acid supplier, potent, competitive, Transportable, EAAT1, EAAT2, EAAT3, EAAT4, EAAT1-4, inhibitors, inhibits, non-transportable, EAAT5, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, L-threo-beta-Hydroxyaspartic, acid, L-threo-b-Hydroxyaspartic, 0183, Tocris Bioscience

1 Citation for L-(-)-threo-3-Hydroxyaspartic acid

Citations are publications that use Tocris products. Selected citations for L-(-)-threo-3-Hydroxyaspartic acid include:

Nakade et al (2018) Gut microbiota-derived D-serine protects against acute kidney injury. JCI Insight 3 PMID: 30333299

Do you know of a great paper that uses L-(-)-threo-3-Hydroxyaspartic acid from Tocris? Please let us know.

Reviews for L-(-)-threo-3-Hydroxyaspartic acid

There are currently no reviews for this product. Be the first to review L-(-)-threo-3-Hydroxyaspartic acid and earn rewards!

Have you used L-(-)-threo-3-Hydroxyaspartic acid?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Huntington's Disease Poster

Huntington's Disease Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.