L-(-)-threo-3-Hydroxyaspartic acid

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Cat.No. 0183 - L-(-)-threo-3-Hydroxyaspartic acid | C4H7NO5 | CAS No. 7298-99-9
Description: Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names: L-threo-β-Hydroxyaspartic acid
Purity: ≥97% (HPLC)

Biological Activity

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.

Technical Data

M. Wt 149.1
Formula C4H7NO5
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 7298-99-9
PubChem ID 443239
Smiles [H][C@@]([C@]([H])(O)C(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 149.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.71 mL 33.53 mL 67.07 mL
5 mM 1.34 mL 6.71 mL 13.41 mL
10 mM 0.67 mL 3.35 mL 6.71 mL
50 mM 0.13 mL 0.67 mL 1.34 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Johnston et al (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 34 241 PMID: 7452241

McBean and Roberts (1985) Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 44 247 PMID: 2856883

Nakamura et al (1993) (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833 PMID: 7901789

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Citations for L-(-)-threo-3-Hydroxyaspartic acid

Citations are publications that use Tocris products.

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