Discontinued Product

L-NNA (Cat. No. 0664) has been withdrawn from sale for commercial reasons.
Cat.No. 0664 - L-NNA | C6H13N5O4 | CAS No. 2149-70-4
Description: NOS inhibitor (nNOS = eNOS >> iNOS)
Chemical Name: NG-Nitro-L-arginine
Purity: ≥99% (HPLC)
Citations (6)
Literature (1)

Biological Activity for L-NNA

NO synthase inhibitor.

Technical Data for L-NNA

M. Wt 219.2
Formula C6H13N5O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2149-70-4
PubChem ID 440005
Smiles N[C@H](C(O)=O)CCCNC(N[N+]([O-])=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for L-NNA

References are publications that support the biological activity of the product.

Dwyer et al (1991) Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem.Biophys.Res.Commun. 176 1136 PMID: 1710109

Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950

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Keywords: L-NNA, L-NNA supplier, NOS, inhibitors, inhibits, nNOS, eNOS, iNOS, Non-Selective, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0664, Tocris Bioscience

6 Citations for L-NNA

Citations are publications that use Tocris products. Selected citations for L-NNA include:

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. J Neurosci 63 383 PMID: 25327839

Pigott et al (2013) On the selectivity of neuronal NOS inhibitors. Br J Pharmacol 168 1255 PMID: 23072468

Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413 PMID: 21235400

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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