L-NNA

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Cat.No. 0664 - L-NNA | C6H13N5O4 | CAS No. 2149-70-4
Description: NOS inhibitor (nNOS = eNOS >> iNOS)
Chemical Name: NG-Nitro-L-arginine
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature

Biological Activity

NO synthase inhibitor.

Technical Data

M. Wt 219.2
Formula C6H13N5O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2149-70-4
PubChem ID 440005
InChI Key MRAUNPAHJZDYCK-BYPYZUCNSA-N
Smiles N[C@H](C(O)=O)CCCNC(N[N+]([O-])=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.1 5

Preparing Stock Solutions

The following data is based on the product molecular weight 219.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 91.24 mL 456.2 mL 912.41 mL
0.25 mM 18.25 mL 91.24 mL 182.48 mL
0.5 mM 9.12 mL 45.62 mL 91.24 mL
2.5 mM 1.82 mL 9.12 mL 18.25 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Dwyer et al (1991) Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem.Biophys.Res.Commun. 176 1136 PMID: 1710109

Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950


If you know of a relevant reference for L-NNA, please let us know.

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Keywords: L-NNA, L-NNA supplier, NOS, inhibitors, inhibits, nNOS, eNOS, iNOS, Non-Selective, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0664, Tocris Bioscience

6 Citations for L-NNA

Citations are publications that use Tocris products. Selected citations for L-NNA include:

Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413 PMID: 21235400

Pigott and Garthwaite (2016) Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus. Front Synaptic Neurosci 8 17 PMID: 27445786

Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278 PMID: 20585660

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. J Neurosci 63 383 PMID: 25327839

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429

Pigott et al (2013) On the selectivity of neuronal NOS inhibitors. Br J Pharmacol 168 1255 PMID: 23072468


Do you know of a great paper that uses L-NNA from Tocris? Please let us know.

Reviews for L-NNA

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nNOS inhibition in cultured brain tissue.
By Anonymous on 11/02/2017
Assay Type: In Vitro
Species: Rat

Bath application on cultured brain slices to block nNOS in plasticity.


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