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Cat.No. 0664 - L-NNA | C6H13N5O4 | CAS No. 2149-70-4
Description: NOS inhibitor (nNOS = eNOS >> iNOS)
Chemical Name: NG-Nitro-L-arginine
Purity: ≥99% (HPLC)
Citations (6)
Reviews (1)
Literature (1)

Biological Activity

NO synthase inhibitor.

Technical Data

M. Wt 219.2
Formula C6H13N5O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2149-70-4
PubChem ID 440005
Smiles N[C@H](C(O)=O)CCCNC(N[N+]([O-])=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 1.1 5

Preparing Stock Solutions

The following data is based on the product molecular weight 219.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 91.24 mL 456.2 mL 912.41 mL
0.25 mM 18.25 mL 91.24 mL 182.48 mL
0.5 mM 9.12 mL 45.62 mL 91.24 mL
2.5 mM 1.82 mL 9.12 mL 18.25 mL

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References are publications that support the biological activity of the product.

Dwyer et al (1991) Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem.Biophys.Res.Commun. 176 1136 PMID: 1710109

Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950

If you know of a relevant reference for L-NNA, please let us know.

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Keywords: L-NNA, L-NNA supplier, NOS, inhibitors, inhibits, nNOS, eNOS, iNOS, Non-Selective, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0664, Tocris Bioscience

6 Citations for L-NNA

Citations are publications that use Tocris products. Selected citations for L-NNA include:

Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278 PMID: 20585660

Pigott et al (2013) On the selectivity of neuronal NOS inhibitors. Br J Pharmacol 168 1255 PMID: 23072468

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. J Neurosci 63 383 PMID: 25327839

Do you know of a great paper that uses L-NNA from Tocris? Please let us know.

Reviews for L-NNA

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nNOS inhibition in cultured brain tissue.
By Anonymous on 11/02/2017
Assay Type: In Vitro
Species: Rat

Bath application on cultured brain slices to block nNOS in plasticity.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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