L-NMMA acetate

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Description: Non-selective NOS inhibitor
Chemical Name: NG-Monomethyl-L-arginine acetate
Citations (6)

Biological Activity for L-NMMA acetate

L-NMMA acetate is a competitive, irreversible inhibitor of all three NOS isoforms.

Technical Data for L-NMMA acetate

M. Wt 248.28
Formula C7H16N4O2.CH3CO2H
Storage Desiccate at RT
CAS Number 53308-83-1
PubChem ID 135242
Smiles CC(O)=O.N=C(NCCC[C@H](N)C(O)=O)NC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-NMMA acetate

Solvent Max Conc. mg/mL Max Conc. mM
water 12.41 50

Preparing Stock Solutions for L-NMMA acetate

The following data is based on the product molecular weight 248.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.06 mL 40.28 mL 80.55 mL
2.5 mM 1.61 mL 8.06 mL 16.11 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
25 mM 0.16 mL 0.81 mL 1.61 mL

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Product Datasheets for L-NMMA acetate

Certificate of Analysis / Product Datasheet
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References for L-NMMA acetate

References are publications that support the biological activity of the product.

Olken et al (1991) Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 177 828 PMID: 2049105

Rees et al (1990) Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 101 746 PMID: 1706208

Reif and McCreedy et al (1995) N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 320 170 PMID: 7540822

Saksuma et al (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 85 8664 PMID: 3263652

If you know of a relevant reference for L-NMMA acetate, please let us know.

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Keywords: L-NMMA acetate, L-NMMA acetate supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, NO, Synthases, nNOS, iNOS, eNOS, Non-selective, 0771, Tocris Bioscience

6 Citations for L-NMMA acetate

Citations are publications that use Tocris products. Selected citations for L-NMMA acetate include:

Schophuizen et al (2015) Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. J Neurosci 4 234 PMID: 26132391

Queval et al (2016) STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. Sci Rep 6 29297 PMID: 27384401

Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146 PMID: 24710004

Carlile et al (2012) An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test. Life Sci 90 267 PMID: 22154905

Do you know of a great paper that uses L-NMMA acetate from Tocris? Please let us know.

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