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Biological Activity for L-NMMA acetate
L-NMMA acetate is a competitive, irreversible inhibitor of all three NOS isoforms.
Technical Data for L-NMMA acetate
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-NMMA acetate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for L-NMMA acetate
The following data is based on the product molecular weight 248.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.06 mL||40.28 mL||80.55 mL|
|2.5 mM||1.61 mL||8.06 mL||16.11 mL|
|5 mM||0.81 mL||4.03 mL||8.06 mL|
|25 mM||0.16 mL||0.81 mL||1.61 mL|
References for L-NMMA acetate
References are publications that support the biological activity of the product.
Olken et al (1991) Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 177 828 PMID: 2049105
Rees et al (1990) Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 101 746 PMID: 1706208
Reif and McCreedy et al (1995) N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 320 170 PMID: 7540822
Saksuma et al (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 85 8664 PMID: 3263652
If you know of a relevant reference for L-NMMA acetate, please let us know.
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Keywords: L-NMMA acetate, L-NMMA acetate supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, NO, Synthases, nNOS, iNOS, eNOS, Non-selective, 0771, Tocris Bioscience
6 Citations for L-NMMA acetate
Citations are publications that use Tocris products. Selected citations for L-NMMA acetate include:
Queval et al (2016) STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. Sci Rep 6 29297 PMID: 27384401
Kurata et al (2004) beta-OE, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-MthD.-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms. J Pharmacol Exp Ther 311 237 PMID: 15175425
Schophuizen et al (2015) Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. J Neurosci 4 234 PMID: 26132391
Carlile et al (2012) An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test. Life Sci 90 267 PMID: 22154905
Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146 PMID: 24710004
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843
Do you know of a great paper that uses L-NMMA acetate from Tocris? Please let us know.
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Literature in this Area
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