L-NMMA acetate

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Cat.No. 0771 - L-NMMA acetate | C7H16N4O2.CH3CO2H | CAS No. 53308-83-1
Description: Non-selective NOS inhibitor
Chemical Name: NG-Monomethyl-L-arginine acetate
Citations (2)

Biological Activity

Competitive, irreversible inhibitor of all three NOS isoforms.

Technical Data

M. Wt 248.28
Formula C7H16N4O2.CH3CO2H
Storage Desiccate at RT
CAS Number 53308-83-1
PubChem ID 135242
Smiles CC(O)=O.N=C(NCCC[C@H](N)C(O)=O)NC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 12.41 50

Preparing Stock Solutions

The following data is based on the product molecular weight 248.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.28 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Olken et al (1991) Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 177 828 PMID: 2049105

Rees et al (1990) Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 101 746 PMID: 1706208

Reif and McCreedy et al (1995) N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 320 170 PMID: 7540822

Saksuma et al (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 85 8664 PMID: 3263652

If you know of a relevant reference for L-NMMA acetate, please let us know.

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Keywords: L-NMMA acetate, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, NO, Synthases, nNOS, iNOS, eNOS, Non-selective, NOS, Non-selective, NOS, Tocris Bioscience

2 Citations for L-NMMA acetate

Citations are publications that use Tocris products. Selected citations for L-NMMA acetate include:

Schophuizen et al (2015) Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. J Neurosci 4 234 PMID: 26132391

Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146 PMID: 24710004

Do you know of a great paper that uses L-NMMA acetate from Tocris? If so please let us know.

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