L-Glutathione Reduced
Biological Activity
Endogenous antioxidant; reduces reactive oxygen species formed during cellular metabolism. Regulates activity of the redox sensitive transcription factor NF-κB. Cytoprotective.
Technical Data
| M. Wt | 307.32 |
| Formula | C10H17N3O6S |
| Storage | Store at +4°C |
| Purity | ≥98% |
| CAS Number | 70-18-8 |
| PubChem ID | 124886 |
| InChI Key | RWSXRVCMGQZWBV-WDSKDSINSA-N |
| Smiles | O=C(N[C@@H](CS)C(NCC(O)=O)=O)CC[C@H](N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 307.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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References
References are publications that support the biological activity of the product.
Sen et al (1999) Glutathione homeostasis in response to exercise training and nutritional supplements. Mol.Cell.Biochem. 196 31 PMID: 10448900
Kerksick et al (2005) The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J.Int.Soc.Sports Nutr. 2 38 PMID: 18500954
If you know of a relevant reference for L-Glutathione Reduced, please let us know.
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Keywords: L-Glutathione Reduced, L-Glutathione Reduced supplier, Endogenous, antioxidant, NF-κB, cellular, metabolism, redox, cytoprotective, neuroprotective, GSH, Antioxidants, Amino, Acids, 5219, Tocris Bioscience
1 Citation for L-Glutathione Reduced
Citations are publications that use Tocris products. Selected citations for L-Glutathione Reduced include:
Das et al (2017) Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling. Sci Rep 7 40773 PMID: 28112165
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MG-63 cells were incubated with GSH (10 μM) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 24 h to follow apoptotic markers using Western blot. GSH inhibited 15d-PGJ2-induced PARP and Caspase-3 cleavage.
Literature in this Area
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Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
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