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Submit ReviewL-Glutathione Reduced
Description: Endogenous antioxidant
Alternative Names: GSH
Chemical Name: L-γ-glutamyl-L-cysteinyl-glycine
Purity: ≥98%
Biological Activity
Endogenous antioxidant; reduces reactive oxygen species formed during cellular metabolism. Regulates activity of the redox sensitive transcription factor NF-κB. Cytoprotective.
Technical Data
| M. Wt | 307.32 |
| Formula | C10H17N3O6S |
| Storage | Store at +4°C |
| Purity | ≥98% |
| CAS Number | 70-18-8 |
| PubChem ID | 124886 |
| InChI Key | RWSXRVCMGQZWBV-WDSKDSINSA-N |
| Smiles | O=C(N[C@@H](CS)C(NCC(O)=O)=O)CC[C@H](N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 307.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Sen et al (1999) Glutathione homeostasis in response to exercise training and nutritional supplements. Mol.Cell.Biochem. 196 31 PMID: 10448900
Kerksick et al (2005) The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J.Int.Soc.Sports Nutr. 2 38 PMID: 18500954
If you know of a relevant reference for L-Glutathione Reduced, please let us know.
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Keywords: L-Glutathione Reduced, L-Glutathione Reduced supplier, Endogenous, antioxidant, NF-κB, cellular, metabolism, redox, cytoprotective, neuroprotective, GSH, Antioxidants, Amino, Acids, 5219, Tocris Bioscience
1 Citation for L-Glutathione Reduced
Citations are publications that use Tocris products. Selected citations for L-Glutathione Reduced include:
Das et al (2017) Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling. Sci Rep 7 40773 PMID: 28112165
Do you know of a great paper that uses L-Glutathione Reduced from Tocris? Please let us know.
Reviews for L-Glutathione Reduced
Average Rating: 5 (Based on 3 Reviews.)
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Great product.
By
Anonymous on 07/02/2019
Species: Human
used at 14mM aq. solution for kinetics experiments.
used it for generating a reducing environment in-vitro
GSH did not inhibit the LPA induced expression of pAMPK in microglia..
By
lisha joshi on 06/18/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: BV2 microglia cells
GSH was used at a concentration 10µM and was well tolerated by the cells. BV2 cells were pre incubated with the inhibitor for one and then treated with 1µM LPA. Western blot analysis revealed that GSH incubation did not abolish the LPA induced expression of pAMPK in BV2 microglia cells.
GSH inhibits 15d-PGJ2-induced apoptosis in osteosarcoma cells.
By
Christopher Trummer on 10/15/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MG-63 osteosarcoma cells
MG-63 cells were incubated with GSH (10 μM) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 24 h to follow apoptotic markers using Western blot. GSH inhibited 15d-PGJ2-induced PARP and Caspase-3 cleavage.
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