L-DON

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Cat.No. 6809 - L-DON | C6H9N3O3 | CAS No. 157-03-9
Description: Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
Chemical Name: 6-Diazo-5-oxo-L-norleucine
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Glutaminase inhibitor (Ki = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.

Technical Data

M. Wt 171.15
Formula C6H9N3O3
Storage Store at -20°C
CAS Number 157-03-9
PubChem ID 9087
InChI Key YCWQAMGASJSUIP-YFKPBYRVSA-N
Smiles N[C@H](C(O)=O)CCC(C=[N+]=[N-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.56 50

Preparing Stock Solutions

The following data is based on the product molecular weight 171.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 11.69 mL 58.43 mL 116.86 mL
2.5 mM 2.34 mL 11.69 mL 23.37 mL
5 mM 1.17 mL 5.84 mL 11.69 mL
25 mM 0.23 mL 1.17 mL 2.34 mL

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References

References are publications that support the biological activity of the product.

Thomas et al (2013) Kinetic characterization of ebselen, chelerythrine and apomor. as glutaminase inhibitors. Biochem.Biophys.Res.Commun. 438 243 PMID: 23850693

Ovejera et al (1979) Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice. Cancer Res. 39 3220 PMID: 572261

Lemberg et al (2018) We're not "DON" yet: optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine. Mol.Cancer Ther. 17 1824 PMID: 30181331


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Keywords: L-DON, L-DON supplier, DON, norleucine, glutaminase, inhibitors, inhibits, Glutaminase, 6809, Tocris Bioscience

Citations for L-DON

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