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Glutaminase inhibitor (Ki = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 171.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||11.69 mL||58.43 mL||116.86 mL|
|2.5 mM||2.34 mL||11.69 mL||23.37 mL|
|5 mM||1.17 mL||5.84 mL||11.69 mL|
|25 mM||0.23 mL||1.17 mL||2.34 mL|
References are publications that support the biological activity of the product.
Thomas et al (2013) Kinetic characterization of ebselen, chelerythrine and apomor. as glutaminase inhibitors. Biochem.Biophys.Res.Commun. 438 243 PMID: 23850693
Ovejera et al (1979) Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice. Cancer Res. 39 3220 PMID: 572261
Lemberg et al (2018) We're not "DON" yet: optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine. Mol.Cancer Ther. 17 1824 PMID: 30181331
If you know of a relevant reference for L-DON, please let us know.
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Keywords: L-DON, L-DON supplier, DON, norleucine, glutaminase, inhibitors, inhibits, Glutaminase, 6809, Tocris Bioscience
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Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.