L-CCG-lll

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Cat.No. 0332 - L-CCG-lll | C6H9NO4 | CAS No. 117857-95-1
Description: Potent, competitive glutamate uptake inhibitor
Alternative Names: (2S,3S,4R)-CCG
Chemical Name: (2S,1'S,2'R)-2-(Carboxycyclopropyl)glycine
Datasheet
Citations
Literature

Biological Activity

Potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate.

Technical Data

M. Wt 159.14
Formula C6H9NO4
Storage Store at RT
CAS Number 117857-95-1
PubChem ID 5310957
InChI Key GZOVEPYOCJWRFC-NUNKFHFFSA-N
Smiles N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@@]([H])1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 159.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.28 mL 31.42 mL 62.84 mL
5 mM 1.26 mL 6.28 mL 12.57 mL
10 mM 0.63 mL 3.14 mL 6.28 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Kawai et al (1992) 2-Carboxycyclopropyl)glycine: binding, neurotoxicity and induction of intracellular free Ca2+ increase. Eur.J.Pharmacol. 211 195 PMID: 1319341

Nakamura et al (1993) (2S,3S,4R)-2-(Carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833 PMID: 7901789

Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213 PMID: 2692753

Yamashita et al (1995) Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-I. Eur.J.Pharmacol. 289 387 PMID: 7621914


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Keywords: L-CCG-lll, supplier, Potent, competitive, reuptake, inhibitors, inhibits, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, (2S,3S,4R)-CCG, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience

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