L-BMAA hydrochloride

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Description: Neurotoxic amino acid
Chemical Name: 3-(Methylamino)-L-alanine hydrochloride
Literature (4)

Biological Activity for L-BMAA hydrochloride

L-BMAA hydrochloride is a neurotoxic glutamate agonist originally isolated from Cycas circinalis. Implicated in the pathogenesis of amyotrophic lateral sclerosis-Parkinsonism-dementia complex of Guam (Guam ALS-PD).

Technical Data for L-BMAA hydrochloride

M. Wt 154.6
Formula C4H10N2O2.HCl
Storage Store at -20°C
CAS Number 16012-55-8
PubChem ID 51358333
Smiles N[C@@H](CNC)C(O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-BMAA hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 9.28 60

Preparing Stock Solutions for L-BMAA hydrochloride

The following data is based on the product molecular weight 154.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.6 mM 10.78 mL 53.9 mL 107.81 mL
3 mM 2.16 mL 10.78 mL 21.56 mL
6 mM 1.08 mL 5.39 mL 10.78 mL
30 mM 0.22 mL 1.08 mL 2.16 mL

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Product Datasheets for L-BMAA hydrochloride

References for L-BMAA hydrochloride

References are publications that support the biological activity of the product.

Weiss et al (1989) Neurotoxicity of β-N-methylamino-L-alanine (BMAA) and β-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons. Brain Res. 497 64 PMID: 2551452

Vega et al (1968) The preparation of L- and D-α-amino-β<-methylaminopropionic acids and the identification of the compound isolated from Cycas circinalis as the L-isomer. Phytochemistry 7 1885

If you know of a relevant reference for L-BMAA hydrochloride, please let us know.

Keywords: L-BMAA hydrochloride, L-BMAA hydrochloride supplier, Neurotoxic, amino, acid, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Miscellaneous, 2538, Tocris Bioscience

Citations for L-BMAA hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.