L-BMAA hydrochloride

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Cat.No. 2538 - L-BMAA hydrochloride | C4H10N2O2.HCl | CAS No. 16012-55-8
Description: Neurotoxic amino acid
Chemical Name: 3-(Methylamino)-L-alanine hydrochloride
Datasheet
Citations
Reviews
Literature

Biological Activity

Neurotoxic glutamate agonist originally isolated from Cycas circinalis. Implicated in the pathogenesis of amyotrophic lateral sclerosis-Parkinsonism-dementia complex of Guam (Guam ALS-PD).

Technical Data

M. Wt 154.6
Formula C4H10N2O2.HCl
Storage Store at -20°C
CAS Number 16012-55-8
PubChem ID 51358333
InChI Key VDXYGASOGLSIDM-DFWYDOINSA-N
Smiles N[C@@H](CNC)C(O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.28 60

Preparing Stock Solutions

The following data is based on the product molecular weight 154.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.6 mM 10.78 mL 53.9 mL 107.81 mL
3 mM 2.16 mL 10.78 mL 21.56 mL
6 mM 1.08 mL 5.39 mL 10.78 mL
30 mM 0.22 mL 1.08 mL 2.16 mL

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References

References are publications that support the biological activity of the product.

Weiss et al (1989) Neurotoxicity of β-N-methylamino-L-alanine (BMAA) and β-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons. Brain Res. 497 64 PMID: 2551452

Vega et al (1968) The preparation of L- and D-α-amino-β<-methylaminopropionic acids and the identification of the compound isolated from Cycas circinalis as the L-isomer. Phytochemistry 7 1885


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Keywords: L-BMAA hydrochloride, L-BMAA hydrochloride supplier, Neurotoxic, amino, acid, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Miscellaneous, 2538, Tocris Bioscience

Citations for L-BMAA hydrochloride

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