L-AP6

Pricing Availability Delivery Time Qty
Cat.No. 0341 - L-AP6 | C6H14NO5P | CAS No. 78944-89-5
Description: Selective agonist of the 'quis' effect
Chemical Name: L-(+)-2-Amino-6-phosphonohexanoic acid
Datasheet
Citations
Literature

Biological Activity

Selective agonist for 'quis'-sensitized site.

Technical Data

M. Wt 211.15
Formula C6H14NO5P
Storage Store at RT
CAS Number 78944-89-5
PubChem ID 3062646
InChI Key QIOXWRQXHFVNLV-YFKPBYRVSA-N
Smiles [H][C@@](CCCCP(O)(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 211.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.74 mL 23.68 mL 47.36 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.74 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Johansen et al (1995) Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats. Mol.Pharmacol. 48 140 PMID: 7623768

Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634

Venkatraman et al (1994) Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus. J.Med.Chem. 37 3939 PMID: 7966155


If you know of a relevant reference for L-AP6, please let us know.

Keywords: L-AP6, supplier, Selective, agonists, quis, effect, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Miscellaneous, Glutamate, Miscellaneous, Glutamate, Tocris Bioscience

Citations for L-AP6

Citations are publications that use Tocris products.

Currently there are no citations for L-AP6. Do you know of a great paper that uses L-AP6 from Tocris? If so please let us know.

L-AP6 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used L-AP6?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Metabotropic Glutamate Receptors

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.