Pricing Availability   Qty
Description: Potent and selective sst5 agonist
Chemical Name: N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
Purity: ≥99% (HPLC)

Biological Activity for L-817,818

L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.

Compound Libraries for L-817,818

L-817,818 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-817,818

M. Wt 536.67
Formula C33H36N4O3
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 217480-27-8
PubChem ID 9937014
Smiles O=C(CC1=C(C4=CC=C(C=CC=C5)C5=C4)NC2=C1C=CC3=C2C=CC=C3)N[C@@H]([C@](OC[C@@H](N)C)=O)CCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-817,818

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.67 100

Preparing Stock Solutions for L-817,818

The following data is based on the product molecular weight 536.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.32 mL 18.63 mL
5 mM 0.37 mL 1.86 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets for L-817,818

Certificate of Analysis / Product Datasheet
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References for L-817,818

References are publications that support the biological activity of the product.

Rohrer et al (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737 PMID: 9784130

Rohrer and Schaeffer (2000) Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 94 211 PMID: 11087999

Strowski et al (2000) Somatostatin inhibits Ins and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141 111 PMID: 10614629

If you know of a relevant reference for L-817,818, please let us know.

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Keywords: L-817,818, L-817,818 supplier, Potent, selective, sst5, agonists, Receptors, Somatostatin, L817818, 1980, Tocris Bioscience

Citations for L-817,818

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