Pricing Availability   Qty
Description: Potent and highly selective EP3 antagonist
Chemical Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
Purity: ≥99% (HPLC)
Citations (7)

Biological Activity for L-798,106

L-798,106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.

Compound Libraries for L-798,106

L-798,106 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-798,106

M. Wt 536.44
Formula C27H22BrNO4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 244101-02-8
PubChem ID 15551229
Smiles O=C(NS(C4=C(OC)C=CC(Br)=C4)(=O)=O)/C=C/C1=CC=CC=C1CC3=CC2=CC=CC=C2C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-798,106

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.64 100

Preparing Stock Solutions for L-798,106

The following data is based on the product molecular weight 536.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.32 mL 18.64 mL
5 mM 0.37 mL 1.86 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for L-798,106

Certificate of Analysis / Product Datasheet
Select another batch:

References for L-798,106

References are publications that support the biological activity of the product.

Juteau et al (2001) Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP3 prostanoid receptor. Bioorg.Med.Chem. 9 1977 PMID: 11504634

Clarke et al (2004) E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype. Br.J.Pharmacol. 141 600 PMID: 14744812

Bassil et al (2008) Activation of prostaglandin EP receptors by lubipro. in rat and human stomach and colon. Br.J.Pharmacol. 154 126 PMID: 18332851

If you know of a relevant reference for L-798,106, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Prostanoid Receptor Antagonists

Keywords: L-798,106, L-798,106 supplier, Potent, selective, EP3, antagonists, Receptors, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L798106, 3342, Tocris Bioscience

7 Citations for L-798,106

Citations are publications that use Tocris products. Selected citations for L-798,106 include:

Ye et al (2018) Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect 7 749 PMID: 29700097

Zhu (2018) Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients. Oncotarget 9 982 PMID: 29416671

Fernández-Galilea et al (2012) Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. J Lipid Res 53 2296 PMID: 22941773

Tunaru et al (2012) Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Cell Commun Signal 109 9179 PMID: 22615395

Do you know of a great paper that uses L-798,106 from Tocris? Please let us know.

Reviews for L-798,106

There are currently no reviews for this product. Be the first to review L-798,106 and earn rewards!

Have you used L-798,106?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review