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Submit ReviewL-759,656
Discontinued Product
L-759,656 (Cat. No. 2434) has been withdrawn from sale for commercial reasons.
Description: Highly selective CB2 agonist
Chemical Name: (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,8,9,10,10a-hexahydro-1-methoxy-6,6-dimethyl-9-methylene-6H-dibenzo[b,d]pyran
Purity: ≥98% (HPLC)
Biological Activity
Highly selective CB2 receptor agonist (Ki values are 11.8 and 4888 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 3.1 nM).
Technical Data
| M. Wt | 384.6 |
| Formula | C26H40O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 174627-56-6 |
| PubChem ID | 5311216 |
| InChI Key | BJIIKHXAZBTGLF-NHCUHLMSSA-N |
| Smiles | C=C1C[C@@H]2[C@H]([C@@](C)(C)OC3=[C@]2C(OC)=CC(C(C)(C)CCCCCC)=C3)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Ross et al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665 PMID: 10188977
Huffman (2005) CB2 receptor ligands. Mini Rev.Med.Chem. 5 641 PMID: 16026310
Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6 1323
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Keywords: L-759,656, L-759,656 supplier, selective, CB2, agonists, cannabinoids, Receptors, cb2r, L759656, 2434, Tocris Bioscience
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