L-759,656

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Cat.No. 2434 - L-759,656 | C26H40O2 | CAS No. 174627-56-6
Description: Highly selective CB2 agonist
Chemical Name: (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,8,9,10,10a-hexahydro-1-methoxy-6,6-dimethyl-9-methylene-6H-dibenzo[b,d]pyran
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly selective CB2 receptor agonist (Ki values are 11.8 and 4888 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 3.1 nM).

Technical Data

M. Wt 384.6
Formula C26H40O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 174627-56-6
PubChem ID 5311216
InChI Key BJIIKHXAZBTGLF-NHCUHLMSSA-N
Smiles C=C1C[C@@H]2[C@H]([C@@](C)(C)OC3=[C@]2C(OC)=CC(C(C)(C)CCCCCC)=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.46 100
ethanol 38.46 100

Preparing Stock Solutions

The following data is based on the product molecular weight 384.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Ross et al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665 PMID: 10188977

Huffman (2005) CB2 receptor ligands. Mini Rev.Med.Chem. 5 641 PMID: 16026310

Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6 1323 PMID:


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Keywords: selective CB2 agonists cannabinoids Receptors cb2r L759656 CB2 Receptors

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