Discontinued Product

L-759,633 (Cat. No. 2433) has been withdrawn from sale for commercial reasons.
Description: High affinity, selective CB2 agonist
Chemical Name: (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for L-759,633

High affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).

Technical Data for L-759,633

M. Wt 384.59
Formula C26H40O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 174627-50-0
PubChem ID 5311215
Smiles CCCCCCC(C)(C)C(C=C3OC)=CC2=[C@@]3[C@H]1[C@H]([C@@](C)(C)O2)CC=C(C)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for L-759,633

References are publications that support the biological activity of the product.

Ross et al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665 PMID: 10188977

Huffman et al (1999) 3-(1',1'-dimethylbutyl)-1-deoxy-D8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595

Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6 1323

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Keywords: L-759,633, L-759,633 supplier, High, affinity, selective, CB2, agonists, cannabinoids, Receptors, cb2r, L759633, 2433, Tocris Bioscience

Citations for L-759,633

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Currently there are no citations for L-759,633.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.