L-693,403 maleate

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Cat.No. 0426 - L-693,403 maleate | C20H23N.C4H4O4 | CAS No. 207455-21-8
Description: High affinity σ ligand
Chemical Name: N-1'-Benzyl-3,4-dihydrospiro[1H-indene-1,4'-piperidine] maleate

Biological Activity

High affinity σ ligand with excellent selectivity over the dopamine D2 receptor.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 393.48
Formula C20H23N.C4H4O4
Storage Desiccate at -20°C
CAS Number 207455-21-8
PubChem ID 56972153
Smiles OC(=O)\C=C/C(O)=O.C(N1CCC2(CCC3=C2C=CC=C3)CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet


References are publications that support the products' biological activity.

Chambers et al (1992) Spiropiperidines as high affinity selective sigma ligands. J.Med.Chem. 35 2033 PMID: 1317923

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