L-692,585

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Cat.No. 2261 - L-692,585 | C32H37N7O3 | CAS No. 145455-35-2
Description: Potent, non-peptide ghrelin receptor agonist
Chemical Name: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.

Technical Data

M. Wt 567.69
Formula C32H37N7O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 145455-35-2
PubChem ID 9872740
InChI Key AYBCFPXLXOLPIZ-JIPXPUAJSA-N
Smiles C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(CC2=CC=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.77 100
ethanol 14.19 25

Preparing Stock Solutions

The following data is based on the product molecular weight 567.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jacks et al (1994) Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J.Endocrinol. 143 399 PMID: 7830002

Glavaski-Joksimovic et al (2002) Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes. J.Endocrinol. 175 625 PMID: 12475374

Smith et al (1999) Peptidomimetic regulation of growth hormone secretion. Endocrine Rev. 18 621 PMID:


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Keywords: Potent non-peptide ghrelin receptors agonists GHS-R1a Receptors Growth Hormone Secretagog 1a Ghrelin L692585 Ghrelin Receptors

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