L-692,585

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Cat.No. 2261 - L-692,585 | C32H37N7O3 | CAS No. 145455-35-2
Description: Potent, non-peptide ghrelin receptor agonist
Chemical Name: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.

Compound Libraries

L-692,585 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 567.69
Formula C32H37N7O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 145455-35-2
PubChem ID 9872740
InChI Key AYBCFPXLXOLPIZ-JIPXPUAJSA-N
Smiles C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(CC2=CC=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.77 100
ethanol 14.19 25

Preparing Stock Solutions

The following data is based on the product molecular weight 567.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Jacks et al (1994) Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl GH secretagogue, on plasma GH, IGF-1, ACTH, cortisol, prolactin, Ins, and thyroxine levels in beagles. J.Endocrinol. 143 399 PMID: 7830002

Glavaski-Joksimovic et al (2002) Mechanism of action of the GH secretagogue, L-692,585, on isolated porcine somatotropes. J.Endocrinol. 175 625 PMID: 12475374

Smith et al (1999) Peptidomimetic regulation of GH secretion. Endocrine Rev. 18 621


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Keywords: L-692,585, L-692,585 supplier, Potent, non-peptide, ghrelin, receptors, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, Ghrelin, L692585, 2261, Tocris Bioscience

1 Citation for L-692,585

Citations are publications that use Tocris products. Selected citations for L-692,585 include:

Evron et al (2014) G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem 289 33442 PMID: 25261469


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Literature in this Area

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