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Submit ReviewL-692,585
Discontinued Product
L-692,585 (Cat. No. 2261) has been withdrawn from sale for commercial reasons.
Description: Potent, non-peptide ghrelin receptor agonist
Chemical Name: 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
Purity: ≥98% (HPLC)
Biological Activity for L-692,585
L-692,585 is a highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.
Compound Libraries for L-692,585
L-692,585 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for L-692,585
| M. Wt | 567.69 |
| Formula | C32H37N7O3 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 145455-35-2 |
| PubChem ID | 9872740 |
| InChI Key | AYBCFPXLXOLPIZ-JIPXPUAJSA-N |
| Smiles | C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(CC2=CC=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-692,585
References for L-692,585
References are publications that support the biological activity of the product.
Jacks et al (1994) Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl GH secretagogue, on plasma GH, IGF-1, ACTH, cortisol, prolactin, Ins, and thyroxine levels in beagles. J.Endocrinol. 143 399 PMID: 7830002
Glavaski-Joksimovic et al (2002) Mechanism of action of the GH secretagogue, L-692,585, on isolated porcine somatotropes. J.Endocrinol. 175 625 PMID: 12475374
Smith et al (1999) Peptidomimetic regulation of GH secretion. Endocrine Rev. 18 621
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Keywords: L-692,585, L-692,585 supplier, Potent, non-peptide, ghrelin, receptors, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, 1a, Ghrelin, L692585, 2261, Tocris Bioscience
1 Citation for L-692,585
Citations are publications that use Tocris products. Selected citations for L-692,585 include:
Evron et al (2014) G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem 289 33442 PMID: 25261469
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.