L-689,560

Pricing Availability   Qty
Description: Highly potent NMDA antagonist
Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews
Literature (5)

Biological Activity for L-689,560

L-689,560 is a very potent antagonist at the glycine-NMDA site.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Compound Libraries for L-689,560

L-689,560 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-689,560

M. Wt 380.23
Formula C17H15Cl2N3O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 139051-78-8
PubChem ID 6604749
InChI Key UCKHICKHGAOGAP-UONOGXRCSA-N
Smiles ClC1=C2C(N[C@@H]([C@](O)=O)C[C@@H]2NC(NC3=CC=CC=C3)=O)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-689,560

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.51 25
ethanol 38.02 100

Preparing Stock Solutions for L-689,560

The following data is based on the product molecular weight 380.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.3 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for L-689,560

Certificate of Analysis / Product Datasheet
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References for L-689,560

References are publications that support the biological activity of the product.

Leeson et al (1992) 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor. J.Med.Chem. 35 1954 PMID: 1534584

Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291

Leeson et al (1991) trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists. Med.Chem.Res. 1 64


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View all NMDA Receptor Antagonists

Keywords: L-689,560, L-689,560 supplier, potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, L689560, merck, 0742, Tocris Bioscience

9 Citations for L-689,560

Citations are publications that use Tocris products. Selected citations for L-689,560 include:

Eales et al (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat Commun 5 4701 PMID: 25134715

Wall et al (2018) The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron 98 1124 PMID: 29861284

Dennis et al (2016) Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus. Mol Brain 26 414 PMID: 26472558

Park et al (2016) Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci 36 622 PMID: 26758849


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Literature in this Area

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