KuWal151

Cat. No. 6644 Submit a Review Datasheet / COA / SDS

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Description: Potent and selective CLK inhibitor

Chemical Name: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KuWal151

KuWal151 is a potent and selective CLK inhibitor (IC₅₀ values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations.

Technical Data for KuWal151

M. Wt	282.72
Formula	C₁₆H₁₁ClN₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
Smiles	O=C1C2=C(CN1)C=CC3=C2NC=C3C4=CC=CC(Cl)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KuWal151

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.27	100
	ethanol	2.83	10 with gentle warming

Preparing Stock Solutions for KuWal151

The following data is based on the product molecular weight 282.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.69 mL	35.37 mL
5 mM	0.71 mL	3.54 mL	7.07 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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Product Datasheets for KuWal151

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for KuWal151

References are publications that support the biological activity of the product.

Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID: 29723265

If you know of a relevant reference for KuWal151, please let us know.

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Citations for KuWal151

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

Receptor Tyrosine Kinases
Protein Kinases A, C, D and G
PI-3 Kinase, Akt and mTOR
MAPK Signaling
Receptor Serine/Threonine Kinases