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Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||2.83||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 282.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.54 mL||17.69 mL||35.37 mL|
|5 mM||0.71 mL||3.54 mL||7.07 mL|
|10 mM||0.35 mL||1.77 mL||3.54 mL|
|50 mM||0.07 mL||0.35 mL||0.71 mL|
References are publications that support the biological activity of the product.
Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID: 29723265
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Keywords: KuWal151, KuWal151 supplier, Clk, inibitors, inhibits, Cdc2-like, kinases, selective, potent, anticancer, CLK, (Cdc2-like, kinases), 6644, Tocris Bioscience
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