Discontinued Product

KuWal151 (Cat. No. 6644) has been withdrawn from sale for commercial reasons.
Description: Potent and selective CLK inhibitor
Chemical Name: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one
Purity: ≥98% (HPLC)

Biological Activity for KuWal151

KuWal151 is a potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations.

Technical Data for KuWal151

M. Wt 282.72
Formula C16H11ClN2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2341841-06-1
Smiles O=C1C2=C(CN1)C=CC3=C2NC=C3C4=CC=CC(Cl)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for KuWal151

References are publications that support the biological activity of the product.

Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID: 29723265

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Keywords: KuWal151, KuWal151 supplier, Clk, inibitors, inhibits, Cdc2-like, kinases, selective, potent, anticancer, CLK, (Cdc2-like, kinases), 6644, Tocris Bioscience

Citations for KuWal151

Citations are publications that use Tocris products.

Currently there are no citations for KuWal151.

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