KuWal151

Pricing Availability   Qty
Description: Potent and selective CLK inhibitor
Chemical Name: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for KuWal151

KuWal151 is a potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations.

Technical Data for KuWal151

M. Wt 282.72
Formula C16H11ClN2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2341841-06-1
Smiles O=C1C2=C(CN1)C=CC3=C2NC=C3C4=CC=CC(Cl)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KuWal151

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.27 100
ethanol 2.83 10 with gentle warming

Preparing Stock Solutions for KuWal151

The following data is based on the product molecular weight 282.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.69 mL 35.37 mL
5 mM 0.71 mL 3.54 mL 7.07 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for KuWal151

References are publications that support the biological activity of the product.

Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID: 29723265


If you know of a relevant reference for KuWal151, please let us know.

View Related Products by Target

View Related Products by Product Action

View all CLK (Cdc2-like Kinase) Inhibitors

Keywords: KuWal151, KuWal151 supplier, Clk, inibitors, inhibits, Cdc2-like, kinases, selective, potent, anticancer, CLK, (Cdc2-like, kinases), 6644, Tocris Bioscience

Citations for KuWal151

Citations are publications that use Tocris products.

Currently there are no citations for KuWal151. Do you know of a great paper that uses KuWal151 from Tocris? Please let us know.

Reviews for KuWal151

There are currently no reviews for this product. Be the first to review KuWal151 and earn rewards!

Have you used KuWal151?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review