Pricing Availability   Qty
Cat.No. 1131 - KU14R | C13H14N2O | CAS No. 189224-48-4
Description: Antagonist of pancreatic imidazoline receptor
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-1H-imidazole
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity

Antagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.

Technical Data

M. Wt 214.27
Formula C13H14N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 189224-48-4
PubChem ID 4302964
Smiles CCC1(CC2=CC=CC=C2O1)C1=NC=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 214.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.67 mL 23.34 mL 46.67 mL
5 mM 0.93 mL 4.67 mL 9.33 mL
10 mM 0.47 mL 2.33 mL 4.67 mL
50 mM 0.09 mL 0.47 mL 0.93 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Chan et al (1997) The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent Ins secretagogue in rat and human islets of Langerhans. Br.J.Pharmacol. 120 926 PMID: 9138700

Chan et al (1997) Clotrimazole and efaroxan stimulate Ins secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch.Pharmacol. 356 763 PMID: 9453462

Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95 PMID: 12409010

If you know of a relevant reference for KU14R, please let us know.

View Related Products by Target

View Related Products by Product Action

View all I3 Receptor Antagonists

Keywords: KU14R, KU14R supplier, Antagonists, pancreatic, imidazoline, receptors, I3, Receptors, 1131, Tocris Bioscience

1 Citation for KU14R

Citations are publications that use Tocris products. Selected citations for KU14R include:

Mourtada et al (1999) Multiple effector pathways regulate the Ins secretory response to the imidazoline RX871024 in isolated rat pancreatic islets. Br J Pharmacol 127 1279 PMID: 10455276

Do you know of a great paper that uses KU14R from Tocris? Please let us know.

Reviews for KU14R

There are currently no reviews for this product. Be the first to review KU14R and earn rewards!

Have you used KU14R?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells