Antagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 214.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.67 mL||23.34 mL||46.67 mL|
|5 mM||0.93 mL||4.67 mL||9.33 mL|
|10 mM||0.47 mL||2.33 mL||4.67 mL|
|50 mM||0.09 mL||0.47 mL||0.93 mL|
References are publications that support the products' biological activity.
Chan et al (1997) The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent insulin secretagogue in rat and human islets of Langerhans. Br.J.Pharmacol. 120 926 PMID: 9138700
Chan et al (1997) Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch.Pharmacol. 356 763 PMID: 9453462
Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95 PMID: 12409010
If you know of a relevant reference for KU14R, please let us know.
View Related Products by Product Action
Keywords: KU14R, supplier, Antagonists, pancreatic, imidazoline, receptors, I3, Receptors, I3, Receptors, I3, Receptors, Tocris Bioscience
Citations for KU14R
Citations are publications that use Tocris products.
Currently there are no citations for KU14R. Do you know of a great paper that uses KU14R from Tocris? If so please let us know.
Reviews for KU14R
There are currently no reviews for this product. Be the first to review KU14R and earn rewards!
Have you used KU14R?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells