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Biological Activity for KT 182
KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.
Technical Data for KT 182
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KT 182
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for KT 182
The following data is based on the product molecular weight 438.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.4 mL||22.8 mL|
|5 mM||0.46 mL||2.28 mL||4.56 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for KT 182
References are publications that support the biological activity of the product.
Hsu et al (2013) Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) J.Med.Chem. 56 8270 PMID: 24152295
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Keywords: KT 182, KT 182 supplier, KT182, potent, selective, irreversible, alpha/beta-hydrolase, α/β, alfa, domains, 6, ABHD6, inhibitors, inhibits, Other, Hydrolases, 6738, Tocris Bioscience
Citations for KT 182
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