KS 176

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Description: Selective BCRP inhibitor
Chemical Name: N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for KS 176

KS 176 is a selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.

Technical Data for KS 176

M. Wt 405.4
Formula C22H19N3O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1253452-78-6
PubChem ID 49779726
Smiles OCCC1=CC=C(NC(C2=C(NC(C3=CC=C([N+]([O-])=O)C=C3)=O)C=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KS 176

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.54 100

Preparing Stock Solutions for KS 176

The following data is based on the product molecular weight 405.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.33 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References for KS 176

References are publications that support the biological activity of the product.

Pick et al (2010) Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 5 1498 PMID: 20632361

If you know of a relevant reference for KS 176, please let us know.

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Citations for KS 176

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