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Biological Activity for KS 176
KS 176 is a selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
Technical Data for KS 176
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KS 176
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for KS 176
The following data is based on the product molecular weight 405.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.47 mL||12.33 mL||24.67 mL|
|5 mM||0.49 mL||2.47 mL||4.93 mL|
|10 mM||0.25 mL||1.23 mL||2.47 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References for KS 176
References are publications that support the biological activity of the product.
Pick et al (2010) Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 5 1498 PMID: 20632361
If you know of a relevant reference for KS 176, please let us know.
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Keywords: KS 176, KS 176 supplier, KS176, selective, inhibitors, inhibits, breast, cancer, resistance, protein, BCRP, multidrug, transporter, ATP-binding, cassettes, Multidrug, Transporters, 4169, Tocris Bioscience
Citations for KS 176
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