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KM 11060 is a corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Robert et al (2008) Structural analog of silde. identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478 PMID: 17975008
Keywords: KM 11060, KM 11060 supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060, pharmacochaperones, CFTR, 3143, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for KM 11060 include:
Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. J Neuroinflammation 8 e82683 PMID: 24367540
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