KM 11060

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Cat.No. 3143 - KM 11060 | C19H17Cl2N3O2S | CAS No. 774549-97-2
Description: Corrects F508del-CFTR trafficking
Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Technical Data

M. Wt 422.33
Formula C19H17Cl2N3O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 774549-97-2
PubChem ID 1241327
InChI Key GIEHIZKCIZLXLF-UHFFFAOYSA-N
Smiles ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.23 100
ethanol 4.22 10

Preparing Stock Solutions

The following data is based on the product molecular weight 422.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Robert et al (2008) Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478 PMID: 17975008


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Keywords: KM 11060, supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060, pharmacochaperones, CFTR, CFTR, Tocris Bioscience

1 Citation for KM 11060

Citations are publications that use Tocris products. Selected citations for KM 11060 include:

Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. J Neuroinflammation 8 e82683 PMID: 24367540


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