Klotho-derived peptide 1

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Description: TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction
Purity: ≥95% (HPLC)
Literature (3)
Pathways (1)

Biological Activity for Klotho-derived peptide 1

Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.

Technical Data for Klotho-derived peptide 1

M. Wt 3228.48
Formula C149H203N39O43
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(NCC(NCC(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC9=CNC=N9)C(NCC(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%10=CC=CC=C%10)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Klotho-derived peptide 1

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Klotho-derived peptide 1

References for Klotho-derived peptide 1

References are publications that support the biological activity of the product.

Yuan et al (2022) A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat.Commun. 13 438 PMID: 35064106

If you know of a relevant reference for Klotho-derived peptide 1, please let us know.

Keywords: Klotho-derived peptide 1, Klotho-derived peptide 1 supplier, TGF-βRII, TGF-β, TGF-betaRII, TGFbRII, TGFbR2, Kinases, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, RSTK, Receptor, Serine/Threonine, RSTKs, KP1, renal, fibrosis, kidney, in, vivo, 7830, Tocris Bioscience

Citations for Klotho-derived peptide 1

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for Klotho-derived peptide 1

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.