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Submit ReviewKLH 45
Description: Potent DDHD2 inhibitor
Chemical Name: N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for KLH 45
KLH 45 is a potent DDHD2 inhibitor (IC50 = 1.3 nM). Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. Active in vivo. Increases brain triacylglycerol levels in mice.
Licensing Information
Sold under license from The Scripps Research Institute
Technical Data for KLH 45
| M. Wt | 458.48 |
| Formula | C24H25F3N4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1632236-44-2 |
| PubChem ID | 126970670 |
| InChI Key | FYOYNRLSBYWAHL-UHFFFAOYSA-N |
| Smiles | O=C(N(C1CCCCC1)CCC2=CC=CC=C2)N(N=C3)N=C3C(C=C4)=CC=C4OC(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for KLH 45
References for KLH 45
References are publications that support the biological activity of the product.
Inloes et al (2014) The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc.Natl.Acad.Sci.U.S.A. 111 14924 PMID: 25267624
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Keywords: KLH 45, KLH 45 supplier, KLH45, DDHD2, inhibits, inhibitors, potent, in, vivo, active, serine, hydrolase, Other, Hydrolases, 5865, Tocris Bioscience
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