KLH 45

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Cat.No. 5865 - KLH 45 | C24H25F3N4O2 | CAS No. 1632236-44-2
Description: Potent DDHD2 inhibitor
Chemical Name: N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent DDHD2 inhibitor (IC50 = 1.3 nM). Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. Active in vivo. Increases brain triacylglycerol levels in mice.

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data

M. Wt 458.48
Formula C24H25F3N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1632236-44-2
PubChem ID 126970670
InChI Key FYOYNRLSBYWAHL-UHFFFAOYSA-N
Smiles O=C(N(C1CCCCC1)CCC2=CC=CC=C2)N(N=C3)N=C3C(C=C4)=CC=C4OC(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.85 100
ethanol 45.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Inloes et al (2014) The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc.Natl.Acad.Sci.U.S.A. 111 14924 PMID: 25267624


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