KISS1 305

Pricing Availability   Qty

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Description: Kisspeptin1 receptor agonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for KISS1 305

KISS1 305 is a potent Kisspeptin1 receptor agonist (EC50 = 10 nM). It binds with high affinity to rat and human KISS1 receptors with Ki values of 0.14 nM and 0.11 nM respectively. In vivo, chronic administration of KISS1 305 reduces plasma testosterone and genital organ weights in male rats.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the KISS1-305 probe summary on the SGC website.

External Portal Information for KISS1 305

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KISS1-305 is reviewed on the chemical probes website.

Technical Data for KISS1 305

M. Wt 1165.32
Formula C56H76N16O12
Sequence YXNSFGLRF

(Modifications: Tyr-1 = D-Tyr, X-2 = D-Pya(4), Gly-6 = AzaGly, Arg-8 = Arg(Me), Phe-9 = C-terminal amide

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 872717-97-0
InChI Key YSVWFFNZZGLLAI-XNTOLAJGSA-N
Smiles O=C(N[C@@H](CCCNC(NC)=N)C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)[C@H](CC(C)C)NC(NNC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](NC([C@@H](CC3=CC=C(C=C3)O)N)=O)CC4=CC=NC=C4)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KISS1 305

Solubility Soluble to 1 mg/ml in water

References for KISS1 305

References are publications that support the biological activity of the product.

Matsui et al (2012) Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats. Endocrinology 153 5297 PMID: 23027808

Asami et al (2013) Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity. J.Med.Chem. 56 8298 PMID: 24047141

Asami et al (2014) Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity. J.Med.Chem. 57 6105 PMID: 24918545

Müller et al (2018) Donated chemical probes for open science. Elife 7 e34311 PMID: 29676732


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Keywords: KISS1 305, KISS1 305 supplier, KISS1305, KISS1, receptors, KISS-derived, Peptide, Kisspeptin10, Kisspeptin, 10, in, vivo, receptor, analog, metastin, Receptor, 7490, Tocris Bioscience

Citations for KISS1 305

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