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Biological Activity for KISS1 305
KISS1 305 is a potent Kisspeptin1 receptor agonist (EC50 = 10 nM). It binds with high affinity to rat and human KISS1 receptors with Ki values of 0.14 nM and 0.11 nM respectively. In vivo, chronic administration of KISS1 305 reduces plasma testosterone and genital organ weights in male rats.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the KISS1-305 probe summary on the SGC website.
External Portal Information for KISS1 305
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KISS1-305 is reviewed on the chemical probes website.
Technical Data for KISS1 305
(Modifications: Tyr-1 = D-Tyr, X-2 = D-Pya(4), Gly-6 = AzaGly, Arg-8 = Arg(Me), Phe-9 = C-terminal amide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KISS1 305
|Solubility||Soluble to 1 mg/ml in water|
References for KISS1 305
References are publications that support the biological activity of the product.
Matsui et al (2012) Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats. Endocrinology 153 5297 PMID: 23027808
Asami et al (2013) Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity. J.Med.Chem. 56 8298 PMID: 24047141
Asami et al (2014) Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity. J.Med.Chem. 57 6105 PMID: 24918545
Müller et al (2018) Donated chemical probes for open science. Elife 7 e34311 PMID: 29676732
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Citations for KISS1 305
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Literature in this Area
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