Endogenous neurotensin-like peptide, originally isolated from pepsin-treated human plasma. Induces histamine release from rat peritoneal mast cells in vitro (ED50 ~ 10 mM).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1172.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.85 mL||4.26 mL||8.53 mL|
|5 mM||0.17 mL||0.85 mL||1.71 mL|
|10 mM||0.09 mL||0.43 mL||0.85 mL|
|50 mM||0.02 mL||0.09 mL||0.17 mL|
References are publications that support the biological activity of the product.
Carraway et al (1987) Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s). J.Biol.Chem. 262 5968 PMID: 2437111
Mogard et al (1986) The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem.Biophys.Res.Commun. 136 938 PMID: 3087352
Sydbom et al (1989) Stimulation of histamine release by the peptide kinetensin. Agents Actions 27 68 PMID: 2473637
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.