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Biological Activity for Kifunensine
Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.
Technical Data for Kifunensine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kifunensine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.16||5 with sonication|
Preparing Stock Solutions for Kifunensine
The following data is based on the product molecular weight 232.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||86.14 mL||430.68 mL||861.36 mL|
|0.25 mM||17.23 mL||86.14 mL||172.27 mL|
|0.5 mM||8.61 mL||43.07 mL||86.14 mL|
|2.5 mM||1.72 mL||8.61 mL||17.23 mL|
References for Kifunensine
References are publications that support the biological activity of the product.
Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820
Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559
If you know of a relevant reference for Kifunensine, please let us know.
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Keywords: Kifunensine, Kifunensine supplier, inhibitors, inhibits, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism, 3207, Tocris Bioscience
1 Citation for Kifunensine
Citations are publications that use Tocris products. Selected citations for Kifunensine include:
Elegheert et al (2018) Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins. Nat Protoc 13 2991 PMID: 30455477
Do you know of a great paper that uses Kifunensine from Tocris? Please let us know.
Reviews for Kifunensine
Average Rating: 5 (Based on 1 Review.)
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