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Description: Inhibitor of class I α-mannosidases
Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Citations (1)
Reviews (1)

Biological Activity for Kifunensine

Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.

Technical Data for Kifunensine

M. Wt 232.19
Formula C8H12N2O6
Storage Store at -20°C
CAS Number 109944-15-2
PubChem ID 130611
Smiles O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N2[C@@]([H])1NC(C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kifunensine

Solvent Max Conc. mg/mL Max Conc. mM
water 1.16 5 with sonication

Preparing Stock Solutions for Kifunensine

The following data is based on the product molecular weight 232.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 86.14 mL 430.68 mL 861.36 mL
0.25 mM 17.23 mL 86.14 mL 172.27 mL
0.5 mM 8.61 mL 43.07 mL 86.14 mL
2.5 mM 1.72 mL 8.61 mL 17.23 mL

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Product Datasheets for Kifunensine

Certificate of Analysis / Product Datasheet
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References for Kifunensine

References are publications that support the biological activity of the product.

Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820

Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559

Xiong et al (2018) Pharmacologic inhibition of N-linked glycan trimming with kifunensine disrupts GLUT1 trafficking and glucose uptake. Int.J.Mol.Sci. 19 890 PMID: 29562594

Hamester et al (2019) Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation. Br.J.Cancer 121 944 PMID: 31659304

If you know of a relevant reference for Kifunensine, please let us know.

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Keywords: Kifunensine, Kifunensine supplier, inhibitors, inhibits, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism, 3207, Tocris Bioscience

1 Citation for Kifunensine

Citations are publications that use Tocris products. Selected citations for Kifunensine include:

Elegheert et al (2018) Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins. Nat Protoc 13 2991 PMID: 30455477

Do you know of a great paper that uses Kifunensine from Tocris? Please let us know.

Reviews for Kifunensine

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works as expected.
By Anonymous on 10/23/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293

1 uM/mL culture for transient transfection in KEK293 cells

time added post transfect did not matter

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