Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.32||10mM with sonication|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.31 mL||21.53 mL||43.07 mL|
|5 mM||0.86 mL||4.31 mL||8.61 mL|
|10 mM||0.43 mL||2.15 mL||4.31 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820
If you know of a relevant reference for Kifunensine, please let us know.
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Keywords: inhibitors inhibits class I α-mannosidase alpha-mannosidases Glycosylases Carbohydrate Metabolism Glycosylases
Citations for Kifunensine
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Literature in this Area
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