Kifunensine

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Cat.No. 3207 - Kifunensine | C8H12N2O6 | CAS No. 109944-15-2
Description: Inhibitor of class I α-mannosidases
Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Datasheet
Citations
Literature

Biological Activity

Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.

Technical Data

M. Wt 232.19
Formula C8H12N2O6
Storage Store at -20°C
CAS Number 109944-15-2
PubChem ID 130611
InChI Key OIURYJWYVIAOCW-PQMKYFCFSA-N
Smiles O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N2[C@@]([H])1NC(C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.32 10mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 232.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.53 mL 43.07 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820

Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559 PMID:


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Keywords: inhibitors inhibits class I α-mannosidase alpha-mannosidases Glycosylases Carbohydrate Metabolism Glycosylases

Citations for Kifunensine

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for Kifunensine

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