Kifunensine

Pricing Availability   Qty
Cat.No. 3207 - Kifunensine | C8H12N2O6 | CAS No. 109944-15-2
Description: Inhibitor of class I α-mannosidases
Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.

Technical Data

M. Wt 232.19
Formula C8H12N2O6
Storage Store at -20°C
CAS Number 109944-15-2
PubChem ID 130611
InChI Key OIURYJWYVIAOCW-PQMKYFCFSA-N
Smiles O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N2[C@@]([H])1NC(C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.32 10 with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 232.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 43.07 mL 215.34 mL 430.68 mL
0.5 mM 8.61 mL 43.07 mL 86.14 mL
1 mM 4.31 mL 21.53 mL 43.07 mL
5 mM 0.86 mL 4.31 mL 8.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820

Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559


If you know of a relevant reference for Kifunensine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycosylase Inhibitors

Keywords: Kifunensine, Kifunensine supplier, inhibitors, inhibits, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism, 3207, Tocris Bioscience

Citations for Kifunensine

Citations are publications that use Tocris products.

Currently there are no citations for Kifunensine. Do you know of a great paper that uses Kifunensine from Tocris? Please let us know.

Reviews for Kifunensine

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Kifunensine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


works as expected.
By Anonymous on 10/23/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293

1 uM/mL culture for transient transfection in KEK293 cells

time added post transfect did not matter

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells