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Inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.32||10 with sonication|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||43.07 mL||215.34 mL||430.68 mL|
|0.5 mM||8.61 mL||43.07 mL||86.14 mL|
|1 mM||4.31 mL||21.53 mL||43.07 mL|
|5 mM||0.86 mL||4.31 mL||8.61 mL|
References are publications that support the biological activity of the product.
Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820
Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559
If you know of a relevant reference for Kifunensine, please let us know.
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Keywords: Kifunensine, Kifunensine supplier, inhibitors, inhibits, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism, 3207, Tocris Bioscience
Citations for Kifunensine
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