Ki 16425

Pricing Availability Delivery Time Qty
Cat.No. 5056 - Ki 16425 | C23H23ClN2O5S | CAS No. 355025-24-0
Description: LPA1 and LPA3 receptor antagonist
Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Technical Data

M. Wt 474.96
Formula C23H23ClN2O5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 355025-24-0
PubChem ID 10367662
InChI Key LLIFMNUXGDHTRO-UHFFFAOYSA-N
Smiles CC1=NOC(C2=CC=C(CSCCC(O)=O)C=C2)=C1NC(OC(C3=CC=CC=C3Cl)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 9.5 20
DMSO 47.5 100
ethanol 47.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 474.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.53 mL 21.05 mL
5 mM 0.42 mL 2.11 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ohta et al (2003) Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol.Pharmacol. 64 994 PMID: 14500756

Yamada et al (2004) Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. J.Biol.Chem. 279 6595 PMID: 14660630

Yu et al (2012) Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150 780 PMID: 22863277


If you know of a relevant reference for Ki 16425, please let us know.

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Keywords: Ki16425 lysophosphatidic acid receptors LPA1 LPA2 LPA3 YAP TAZ HIPPO Lysophosphatidic Acid Receptors

1 Citation for Ki 16425

Citations are publications that use Tocris products. Selected citations for Ki 16425 include:

Evseenko et al (2013) Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One 8 e63718 PMID: 23696850


Do you know of a great paper that uses Ki 16425 from Tocris? If so please let us know.

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