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Description: HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for KC7F2

KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Technical Data for KC7F2

M. Wt 570.38
Formula C16H16Cl4N2O4S4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 927822-86-4
PubChem ID 16047442
Smiles ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KC7F2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 57.04 100

Preparing Stock Solutions for KC7F2

The following data is based on the product molecular weight 570.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.75 mL 8.77 mL 17.53 mL
5 mM 0.35 mL 1.75 mL 3.51 mL
10 mM 0.18 mL 0.88 mL 1.75 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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References for KC7F2

References are publications that support the biological activity of the product.

Narita et al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128 PMID: 19789328

Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945 PMID: 19789327

If you know of a relevant reference for KC7F2, please let us know.

View Related Products by Product Action

View all Hypoxia Inducible Factor (HIF) Inhibitors

Keywords: KC7F2, KC7F2 supplier, KC7F2, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, inhibits, hypoxia-inducible, factors, downregulators, down-regulators, downregulation, down-regulation, Hypoxia, Inducible, Factors, 4324, Tocris Bioscience

2 Citations for KC7F2

Citations are publications that use Tocris products. Selected citations for KC7F2 include:

Hannes M et al (2020) LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes. Front Immunol 11 353 PMID: 32210962

Dean H et al (2020) Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Sci Rep 10 8388 PMID: 32433492

Do you know of a great paper that uses KC7F2 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.