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KC7F2

Cat. No. 4324 Submit a Review Datasheet / COA / SDS
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Description: HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KC7F2

KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Technical Data for KC7F2

M. Wt 570.38
Formula C16H16Cl4N2O4S4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 927822-86-4
PubChem ID 16047442
InChI Key REQLACDIZMLXIC-UHFFFAOYSA-N
Smiles ClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KC7F2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.04 100

Preparing Stock Solutions for KC7F2

The following data is based on the product molecular weight 570.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.75 mL 8.77 mL 17.53 mL
5 mM 0.35 mL 1.75 mL 3.51 mL
10 mM 0.18 mL 0.88 mL 1.75 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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References for KC7F2

References are publications that support the biological activity of the product.

Narita et al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128 PMID: 19789328

Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945 PMID: 19789327

If you know of a relevant reference for KC7F2, please let us know.

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Citations for KC7F2

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