kb NB 142-70

Pricing Availability Delivery Time Qty
Cat.No. 3962 - kb NB 142-70 | C11H9NO2S2 | CAS No. 1233533-04-4
Description: Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
Chemical Name: 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.

Technical Data

M. Wt 251.32
Formula C11H9NO2S2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1233533-04-4
PubChem ID 45258277
InChI Key DHUAGGSHTKPOHU-UHFFFAOYSA-N
Smiles OC1=CC=C(SC3=C2SCCNC3=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 251.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.89 mL 39.79 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

LaValle et al (2010) Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 10 5 PMID: 20444281

Bravo-Altamirano et al (2011) Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2 154 PMID: 21617763

Ni et al (2013) PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 8 e73149 PMID: 24039875


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Keywords: PKD protein kinase D inhibitor analog selective inhibitors inhibits analogs kbNB142-70 Protein Kinase D

1 Citation for kb NB 142-70

Citations are publications that use Tocris products. Selected citations for kb NB 142-70 include:

Weber et al (2015) A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol 9 9 PMID: 25889812


Do you know of a great paper that uses kb NB 142-70 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for kb NB 142-70

Protocols

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