kb NB 142-70
Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 251.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.98 mL||19.89 mL||39.79 mL|
|5 mM||0.8 mL||3.98 mL||7.96 mL|
|10 mM||0.4 mL||1.99 mL||3.98 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
LaValle et al (2010) Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 10 5 PMID: 20444281
Bravo-Altamirano et al (2011) Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2 154 PMID: 21617763
Ni et al (2013) PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 8 e73149 PMID: 24039875
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Keywords: PKD protein kinase D inhibitor analog selective inhibitors inhibits analogs kbNB142-70 Protein Kinase D
1 Citation for kb NB 142-70
Citations are publications that use Tocris products. Selected citations for kb NB 142-70 include:
Weber et al (2015) A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol 9 9 PMID: 25889812
Do you know of a great paper that uses kb NB 142-70 from Tocris? If so please let us know.