JWH 015

Pricing Availability Delivery Time Qty
Cat.No. 1341 - JWH 015 | C23H21NO | CAS No. 155471-08-2
Description: Selective CB2 agonist
Chemical Name: (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Literature

Biological Activity

Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).

Technical Data

M. Wt 327.43
Formula C23H21NO
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 155471-08-2
PubChem ID 4273754
InChI Key LJSBBBWQTLXQEN-UHFFFAOYSA-N
Smiles CCCN1C(C)=C(C(=O)C2=CC=CC3=CC=CC=C23)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in DMSO and to 25 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 327.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.27 mL 30.54 mL
5 mM 0.61 mL 3.05 mL 6.11 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837 PMID: 10525107

Griffin et al (1997) Evidence for the presence of CB2-like receptor on peripheral nerve terminals. Eur.J.Pharmacol. 339 53 PMID: 9450616

Pertwee et al (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884


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Keywords: Selective CB2 agonists Cannabinoids Receptors JWH015 cb2r CB2 Receptors

8 Citations for JWH 015

Citations are publications that use Tocris products. Selected citations for JWH 015 include:

Agudelo et al (2016) Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol 6 1452 PMID: 26733986

Verty et al (2015) Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice. PLoS One 10 e0140592 PMID: 26588700

Preet et al (2011) Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila) 4 65 PMID: 21097714

DiPatrizio et al (2011) Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A 108 12904 PMID: 21730161

McGuinness et al (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Mol Pharmacol 14 49 PMID: 19171920

Börner et al (2006) Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Cell Neurosci 69 1486 PMID: 16434616

Ehrhart et al (2005) Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29 PMID: 16343349

Jiang et al Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One 2 e641 PMID: 17653268


Do you know of a great paper that uses JWH 015 from Tocris? If so please let us know.

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Pathways for JWH 015

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