JW 480

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Cat.No. 4327 - JW 480 | C22H23NO2 | CAS No. 1354359-53-7
Description: Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
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Citations
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Biological Activity

Potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo. Reduces monoalkylglycerol ether (MAGE) levels.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data

M. Wt 333.42
Formula C22H23NO2
Storage Store at -20°C
CAS Number 1354359-53-7
PubChem ID 57330099
InChI Key PCNJGBMWAZRVEA-UHFFFAOYSA-N
Smiles CC(C)C1=CC=CC=C1OC(NCCC2=CC=C(C=CC=C3)C3=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.34 100
ethanol 33.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 333.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References

References are publications that support the products' biological activity.

Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476 PMID: 21513884


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Keywords: JW 480, supplier, KIAA1363, inhibitors, inhibits, KIAA, 1363, prostate, cancer, AADACL1, MAGE, monoalkylglycerol, ether, JW480, Other, Hydrolases, Tocris Bioscience

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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