JW 480

Pricing Availability   Qty
Description: Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
Purity: ≥98% (HPLC)

Biological Activity for JW 480

JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data for JW 480

M. Wt 333.42
Formula C22H23NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1354359-53-7
PubChem ID 57330099
Smiles CC(C)C1=CC=CC=C1OC(NCCC2=CC=C(C=CC=C3)C3=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JW 480

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.34 100
ethanol 33.34 100

Preparing Stock Solutions for JW 480

The following data is based on the product molecular weight 333.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for JW 480

Certificate of Analysis / Product Datasheet
Select another batch:

References for JW 480

References are publications that support the biological activity of the product.

Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476 PMID: 21513884

If you know of a relevant reference for JW 480, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Hydrolase Inhibitors

Keywords: JW 480, JW 480 supplier, KIAA1363, inhibitors, inhibits, KIAA, 1363, prostate, cancer, AADACL1, MAGE, monoalkylglycerol, ether, JW480, neutral, cholesterol, ester, hydrolase, 1, NCEH1, Other, Hydrolases, 4327, Tocris Bioscience

Citations for JW 480

Citations are publications that use Tocris products.

Currently there are no citations for JW 480. Do you know of a great paper that uses JW 480 from Tocris? Please let us know.

Reviews for JW 480

There are currently no reviews for this product. Be the first to review JW 480 and earn rewards!

Have you used JW 480?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review