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Submit ReviewJTV 519 fumarate
Description: Ryanodine receptor (RyR) inhibitor
Alternative Names: K 201
Chemical Name: 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Purity: ≥97% (HPLC)
Biological Activity for JTV 519 fumarate
JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.
Technical Data for JTV 519 fumarate
| M. Wt | 540.67 |
| Formula | C25H32N2O2S.C4H4O4 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1883549-36-7 |
| PubChem ID | 91826075 |
| InChI Key | ISLOBKLDZGDFTB-WLHGVMLRSA-N |
| Smiles | O=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JTV 519 fumarate
References for JTV 519 fumarate
References are publications that support the biological activity of the product.
Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID: 17313373
Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID: 17994112
Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID: 21989257
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Keywords: JTV 519 fumarate, JTV 519 fumarate supplier, JTV519, fumarate, K201, ryanodine, receptors, inhibitors, inhibits, ryr1, ryr2, antiarrythmic, cardioprotective, K, 201, Ryanodine, Receptors, 4564, Tocris Bioscience
2 Citations for JTV 519 fumarate
Citations are publications that use Tocris products. Selected citations for JTV 519 fumarate include:
Chih-Cheng et al (2021) ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10 PMID: 34569932
Andreia S et al (2023) Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells. Cell Rep Methods 3 100456 PMID: 37159667
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