You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
JTV 519 fumarate
Biological Activity for JTV 519 fumarate
JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.
Technical Data for JTV 519 fumarate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JTV 519 fumarate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JTV 519 fumarate
The following data is based on the product molecular weight 540.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.25 mL||18.5 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
|10 mM||0.18 mL||0.92 mL||1.85 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
Product Datasheets for JTV 519 fumarate
References for JTV 519 fumarate
References are publications that support the biological activity of the product.
Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID: 17313373
Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID: 17994112
Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID: 21989257
If you know of a relevant reference for JTV 519 fumarate, please let us know.
View Related Products by Product Action
Keywords: JTV 519 fumarate, JTV 519 fumarate supplier, JTV519, fumarate, K201, ryanodine, receptors, inhibitors, inhibits, ryr1, ryr2, antiarrythmic, cardioprotective, K, 201, Ryanodine, Receptors, 4564, Tocris Bioscience
2 Citations for JTV 519 fumarate
Citations are publications that use Tocris products. Selected citations for JTV 519 fumarate include:
Andreia S et al (2023) Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells. Cell Rep Methods 3 100456 PMID: 37159667
Chih-Cheng et al (2021) ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10 PMID: 34569932
Do you know of a great paper that uses JTV 519 fumarate from Tocris? Please let us know.
Reviews for JTV 519 fumarate
There are currently no reviews for this product. Be the first to review JTV 519 fumarate and earn rewards!
Have you used JTV 519 fumarate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image