JTV 519 fumarate
Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 540.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.25 mL||18.5 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
|10 mM||0.18 mL||0.92 mL||1.85 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID: 17313373
Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID: 17994112
Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID: 21989257
If you know of a relevant reference for JTV 519 fumarate, please let us know.
View Related Products by Product Action
Keywords: JTV 519 fumarate, supplier, JTV519, fumarate, K201, ryanodine, receptors, inhibitors, inhibits, ryr1, ryr2, antiarrythmic, cardioprotective, K, 201, Ryanodine, Receptors, Ryanodine, Receptors, Tocris Bioscience
Citations for JTV 519 fumarate
Citations are publications that use Tocris products.
Currently there are no citations for JTV 519 fumarate. Do you know of a great paper that uses JTV 519 fumarate from Tocris? If so please let us know.