JTP 103237

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Cat.No. 6765 - JTP 103237 | C24H29F3N6O | CAS No. 1883864-16-1
Description: Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor
Chemical Name: 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.

Technical Data

M. Wt 474.52
Formula C24H29F3N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1883864-16-1
PubChem ID 91884614
InChI Key KELNXHBJTXCXSN-UHFFFAOYSA-N
Smiles CC(C)(C1=CC(C(C)(C)C)=NC(N2CCN3C(C2)=NN=C3C4=CC=C(C=C4)OC(F)(F)F)=N1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 47.45 100
DMSO 9.49 20

Preparing Stock Solutions

The following data is based on the product molecular weight 474.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.07 mL
5 mM 0.42 mL 2.11 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References

References are publications that support the biological activity of the product.

Okuma et al (2015) JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur.J.Pharmacol. 758 72 PMID: 25857225

Okuma et al (2015) JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J.Pharmacol.Sci. 128 150 PMID: 26215699


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Keywords: JTP 103237, JTP 103237 supplier, JTP103237, monoacyglycerol, acyltransferase, MGAT2, inhibitors, inhibits, potent, selective, antiobesity, triglyceride, synthesis, DGAT2L, MOGAT2, Other, Transferases, Lipid, Metabolism, 6765, Tocris Bioscience

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