JNJ 63533054

Pricing Availability Delivery Time Qty
Cat.No. 5666 - JNJ 63533054 | C17H17ClN2O2 | CAS No. 1802326-66-4
Description: Potent and selective GPR139 agonist
Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Technical Data

M. Wt 316.78
Formula C17H17ClN2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1802326-66-4
PubChem ID 2548547
InChI Key MWDVCHRYCKXEBY-LBPRGKRZSA-N
Smiles O=C(CNC(C1=CC=CC(Cl)=C1)=O)N[C@@H](C)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 100
ethanol 6.34 20

Preparing Stock Solutions

The following data is based on the product molecular weight 316.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.57 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Dvorak et al (2015) Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 6 1015 PMID: 26396690


If you know of a relevant reference for JNJ 63533054, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Orphan 7-TM Receptor Agonists

Keywords: JNJ63533054 GPR139 agonists agonism potent selective orally available brain penetrant orphan 7-TM receptors Orphan 7-TM Receptors

Citations for JNJ 63533054

Citations are publications that use Tocris products.

Currently there are no citations for JNJ 63533054. Do you know of a great paper that uses JNJ 63533054 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for JNJ 63533054

Protocols

TODO: Add Protocols