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Biological Activity for JNJ 63533054
JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.
Compound Libraries for JNJ 63533054
Technical Data for JNJ 63533054
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 63533054
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JNJ 63533054
The following data is based on the product molecular weight 316.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.16 mL||15.78 mL||31.57 mL|
|5 mM||0.63 mL||3.16 mL||6.31 mL|
|10 mM||0.32 mL||1.58 mL||3.16 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References for JNJ 63533054
References are publications that support the biological activity of the product.
Dvorak et al (2015) Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 6 1015 PMID: 26396690
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Keywords: JNJ 63533054, JNJ 63533054 supplier, JNJ63533054, GPR139, agonists, agonism, potent, selective, orally, available, brain, penetrant, orphan, 7-TM, receptors, Orphan, Receptors, 5666, Tocris Bioscience
1 Citation for JNJ 63533054
Citations are publications that use Tocris products. Selected citations for JNJ 63533054 include:
Susumu et al (2021) Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway. iScience 24 102504 PMID: 34113835
Do you know of a great paper that uses JNJ 63533054 from Tocris? Please let us know.
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