JNJ 63533054

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Description: Potent and selective GPR139 agonist
Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for JNJ 63533054

JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Compound Libraries for JNJ 63533054

JNJ 63533054 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 63533054

M. Wt 316.78
Formula C17H17ClN2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1802326-66-4
PubChem ID 2548547
Smiles O=C(CNC(C1=CC=CC(Cl)=C1)=O)N[C@@H](C)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 63533054

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.68 100
ethanol 6.34 20

Preparing Stock Solutions for JNJ 63533054

The following data is based on the product molecular weight 316.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.57 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for JNJ 63533054

References are publications that support the biological activity of the product.

Dvorak et al (2015) Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 6 1015 PMID: 26396690

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1 Citation for JNJ 63533054

Citations are publications that use Tocris products. Selected citations for JNJ 63533054 include:

Susumu et al (2021) Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway. iScience 24 102504 PMID: 34113835

Do you know of a great paper that uses JNJ 63533054 from Tocris? Please let us know.

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