JNJ 63533054

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Cat.No. 5666 - JNJ 63533054 | C17H17ClN2O2 | CAS No. 1802326-66-4
Description: Potent and selective GPR139 agonist
Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Technical Data

M. Wt 316.78
Formula C17H17ClN2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1802326-66-4
PubChem ID 2548547
InChI Key MWDVCHRYCKXEBY-LBPRGKRZSA-N
Smiles O=C(CNC(C1=CC=CC(Cl)=C1)=O)N[C@@H](C)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 100
ethanol 6.34 20

Preparing Stock Solutions

The following data is based on the product molecular weight 316.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.78 mL 31.57 mL
5 mM 0.63 mL 3.16 mL 6.31 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Dvorak et al (2015) Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 6 1015 PMID: 26396690


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Literature in this Area

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