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Biological Activity for JNJ 5207787
JNJ 5207787 is a selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
Sold with the permission of Janssen Pharmaceutica N.V.
Technical Data for JNJ 5207787
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 5207787
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.11||10 with gentle warming|
|ethanol||5.11||10 with gentle warming|
Preparing Stock Solutions for JNJ 5207787
The following data is based on the product molecular weight 510.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.58 mL||97.91 mL||195.82 mL|
|0.5 mM||3.92 mL||19.58 mL||39.16 mL|
|1 mM||1.96 mL||9.79 mL||19.58 mL|
|5 mM||0.39 mL||1.96 mL||3.92 mL|
References for JNJ 5207787
References are publications that support the biological activity of the product.
Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130 PMID: 14617685
Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239 PMID: 14980673
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Keywords: JNJ 5207787, JNJ 5207787 supplier, JNJ5207787, neuropeptide, y, NPY, Y2, antagonists, selective, Receptors, 4018, Tocris Bioscience
Citations for JNJ 5207787
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.