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Selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
Sold with the permission of Janssen Pharmaceutica N.V.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.11||10 with gentle warming|
|ethanol||5.11||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 510.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.58 mL||97.91 mL||195.82 mL|
|0.5 mM||3.92 mL||19.58 mL||39.16 mL|
|1 mM||1.96 mL||9.79 mL||19.58 mL|
|5 mM||0.39 mL||1.96 mL||3.92 mL|
References are publications that support the biological activity of the product.
Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130 PMID: 14617685
Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239 PMID: 14980673
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Keywords: JNJ 5207787, JNJ 5207787 supplier, JNJ5207787, neuropeptide, y, NPY, Y2, antagonists, selective, Receptors, 4018, Tocris Bioscience
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Literature in this Area
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