JNJ 5207787

Discontinued Product

JNJ 5207787 (Cat. No. 4018) has been withdrawn from sale for commercial reasons.
Description: Selective NPY Y2 receptor antagonist
Chemical Name: (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for JNJ 5207787

JNJ 5207787 is a selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Technical Data for JNJ 5207787

M. Wt 510.67
Formula C32H38N4O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 683746-68-1
PubChem ID 10324083
Smiles O=C(C)N2CCC1=CC=C(N(C(/C=C/C5=CC=CC(C#N)=C5)=O)C3CCN(CCC4CCCC4)CC3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for JNJ 5207787

References are publications that support the biological activity of the product.

Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130 PMID: 14617685

Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239 PMID: 14980673

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Keywords: JNJ 5207787, JNJ 5207787 supplier, JNJ5207787, neuropeptide, y, NPY, Y2, antagonists, selective, Receptors, 4018, Tocris Bioscience

Citations for JNJ 5207787

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Currently there are no citations for JNJ 5207787.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.