JMS 17-2 hydrochloride

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Cat.No. 6378 - JMS 17-2 hydrochloride | C25H26ClN3O.HCl
Description: CX3CR1 antagonist
Chemical Name: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.

Technical Data

M. Wt 456.41
Formula C25H26ClN3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
Smiles ClC1=CC=C(C2CCN(CC2)CCCN3C(C4=CC=CN4C5=CC=CC=C35)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.64 100
ethanol 22.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 456.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.96 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Shen et al (2016) Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res. 14 518 PMID: 27001765


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Keywords: JMS 17-2 hydrochloride, JMS 17-2 hydrochloride supplier, JMS17-2, hydrochloride, HCl, 1380392-05-1, fractalkine, receptor, antagonists, antagonism, cx3cr1, chemokines, Other, Chemokine, Receptors, 6378, Tocris Bioscience

Citations for JMS 17-2 hydrochloride

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Literature in this Area

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