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Biological Activity for Jedi2
Jedi2 is a piezo1 channel activator. Promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels. Elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.
Compound Libraries for Jedi2
Technical Data for Jedi2
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Jedi2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Jedi2
The following data is based on the product molecular weight 208.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.8 mL||24.01 mL||48.02 mL|
|5 mM||0.96 mL||4.8 mL||9.6 mL|
|10 mM||0.48 mL||2.4 mL||4.8 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References for Jedi2
References are publications that support the biological activity of the product.
Wang et al (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 9 1300 PMID: 29610524
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Keywords: Jedi2, Jedi2 supplier, Jedi2, Piezo1, calcium, channels, activators, activates, Ca2+, currents, mechanotransduction, mechanosensitive, Piezo, Channels, 6614, Tocris Bioscience
1 Citation for Jedi2
Citations are publications that use Tocris products. Selected citations for Jedi2 include:
Yuri et al (2021) Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis. Int J Mol Sci 22 PMID: 34360605
Do you know of a great paper that uses Jedi2 from Tocris? Please let us know.
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