Jedi2

Pricing Availability   Qty
Cat.No. 6614 - Jedi2 | C10H8O3S | CAS No. 651005-90-2
Description: Piezo1 channel activator
Chemical Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Piezo1 channel activator. Promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels. Elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.

Technical Data

M. Wt 208.23
Formula C10H8O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 651005-90-2
PubChem ID 2796026
InChI Key YXDCRSXNEOKXDE-UHFFFAOYSA-N
Smiles CC1=C(C(O)=O)C=C(C2=CC=CS2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.82 100
ethanol 20.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 208.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.8 mL 24.01 mL 48.02 mL
5 mM 0.96 mL 4.8 mL 9.6 mL
10 mM 0.48 mL 2.4 mL 4.8 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Wang et al (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 9 1300 PMID: 29610524


If you know of a relevant reference for Jedi2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Piezo Channel Activators

Keywords: Jedi2, Jedi2 supplier, Jedi2, Piezo1, calcium, channels, activators, activates, Ca2+, currents, mechanotransduction, mechanosensitive, Piezo, Channels, 6614, Tocris Bioscience

Citations for Jedi2

Citations are publications that use Tocris products.

Currently there are no citations for Jedi2. Do you know of a great paper that uses Jedi2 from Tocris? Please let us know.

Reviews for Jedi2

There are currently no reviews for this product. Be the first to review Jedi2 and earn rewards!

Have you used Jedi2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.