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Description: Piezo1 channel activator
Chemical Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Jedi2

Jedi2 is a piezo1 channel activator. Promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels. Elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.

Compound Libraries for Jedi2

Jedi2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Jedi2

M. Wt 208.23
Formula C10H8O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 651005-90-2
PubChem ID 2796026
Smiles CC1=C(C(O)=O)C=C(C2=CC=CS2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Jedi2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.82 100
ethanol 20.82 100

Preparing Stock Solutions for Jedi2

The following data is based on the product molecular weight 208.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.8 mL 24.01 mL 48.02 mL
5 mM 0.96 mL 4.8 mL 9.6 mL
10 mM 0.48 mL 2.4 mL 4.8 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets for Jedi2

Certificate of Analysis / Product Datasheet
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References for Jedi2

References are publications that support the biological activity of the product.

Wang et al (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 9 1300 PMID: 29610524

If you know of a relevant reference for Jedi2, please let us know.

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Keywords: Jedi2, Jedi2 supplier, Jedi2, Piezo1, calcium, channels, activators, activates, Ca2+, currents, mechanotransduction, mechanosensitive, Piezo, Channels, 6614, Tocris Bioscience

1 Citation for Jedi2

Citations are publications that use Tocris products. Selected citations for Jedi2 include:

Yuri et al (2021) Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis. Int J Mol Sci 22 PMID: 34360605

Do you know of a great paper that uses Jedi2 from Tocris? Please let us know.

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