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Description: Potent PORCN inhibitor; active in vivo
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity: ≥98% (HPLC)
Biological Activity for IWP 12
IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.
Technical Data for IWP 12
| M. Wt | 418.56 |
| Formula | C18H18N4O2S3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 688353-45-9 |
| PubChem ID | 3244448 |
| InChI Key | RBFDSBJDWZOTGR-UHFFFAOYSA-N |
| Smiles | CC(S1)CC2=C1C(N(C)C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)=N2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for IWP 12
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.86 | 100 |
Preparing Stock Solutions for IWP 12
The following data is based on the product molecular weight 418.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.95 mL | 23.89 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for IWP 12
References for IWP 12
References are publications that support the biological activity of the product.
Dodge et al (2012) Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 287 23246 PMID: 22593577
If you know of a relevant reference for IWP 12, please let us know.
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Keywords: IWP 12, IWP 12 supplier, IWP12, potent, porcupine, porcn, wnt, bcatenin, beta_catenin, βcatenin, MBOAT, membrane-bound, O-acyltransferases, PORCN, 5279, Tocris Bioscience
Citations for IWP 12
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