IWP 12

Pricing Availability Delivery Time Qty
Cat.No. 5279 - IWP 12 | C18H18N4O2S3 | CAS No. 688353-45-9
Description: Potent PORCN inhibitor; active in vivo
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity: ≥98% (HPLC)

Biological Activity

Potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Technical Data

M. Wt 418.56
Formula C18H18N4O2S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 688353-45-9
PubChem ID 3244448
Smiles CC(S1)CC2=C1C(N(C)C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 418.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Dodge et al (2012) Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 287 23246 PMID: 22593577

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Keywords: IWP 12, supplier, IWP12, potent, porcupine, porcn, wnt, bcatenin, beta_catenin, βcatenin, MBOAT, membrane-bound, O-acyltransferases, PORCN, PORCN, Tocris Bioscience

Citations for IWP 12

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Literature in this Area


Cancer Research Product Guide

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Pathways for IWP 12


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