IWP 12

Discontinued Product

5279 has been discontinued.

View all PORCN products.
Description: Potent PORCN inhibitor; active in vivo
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for IWP 12

IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Technical Data for IWP 12

M. Wt 418.56
Formula C18H18N4O2S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 688353-45-9
PubChem ID 3244448
InChI Key RBFDSBJDWZOTGR-UHFFFAOYSA-N
Smiles CC(S1)CC2=C1C(N(C)C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for IWP 12

References are publications that support the biological activity of the product.

Dodge et al (2012) Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 287 23246 PMID: 22593577

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Keywords: IWP 12, IWP 12 supplier, IWP12, potent, porcupine, porcn, wnt, bcatenin, beta_catenin, βcatenin, MBOAT, membrane-bound, O-acyltransferases, PORCN, 5279, Tocris Bioscience

Citations for IWP 12

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Currently there are no citations for IWP 12.

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