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Submit ReviewIvabradine hydrochloride
Description: HCN channel blocker; inhibits If pacemaker current
Chemical Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Ivabradine hydrochloride
Ivabradine hydrochloride is a HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.
Compound Libraries for Ivabradine hydrochloride
Ivabradine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Ivabradine hydrochloride
| M. Wt | 505.05 |
| Formula | C27H36N2O5.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 148849-67-6 |
| PubChem ID | 3045381 |
| InChI Key | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| Smiles | COC1=C(C=C2[C@H](CC2=C1)CN(CCCN3CCC4=CC(OC)=C(C=C4CC3=O)OC)C)OC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ivabradine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.51 | 100 | |
| DMSO | 50.51 | 100 |
Preparing Stock Solutions for Ivabradine hydrochloride
The following data is based on the product molecular weight 505.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.9 mL | 19.8 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for Ivabradine hydrochloride
References for Ivabradine hydrochloride
References are publications that support the biological activity of the product.
Thollon et al (1994) Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br.J.Pharmacol. 112 37 PMID: 8032660
Novella Romanelli et al (2016) HCN channel modulators: the need for selectivity. Curr.Top.Med.Chem. 16 1764 PMID: 26975509
If you know of a relevant reference for Ivabradine hydrochloride, please let us know.
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Keywords: Ivabradine hydrochloride, Ivabradine hydrochloride supplier, Ivabradine, HCL, HCN, blockers, blocks, bradycardic, agents, hyperpolarization, activated, current, If, inhibitors, inhibits, pacemaker, Channels, 6542, Tocris Bioscience
Citations for Ivabradine hydrochloride
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Reviews for Ivabradine hydrochloride
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Effect of ivabradine on pacemaker of human atrial myocytes.
By
Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: primary atrial cardiomyocytes
Primary human atrial cardiomyocytes were patched to analyze mean current-voltage relationships of pacemaker current (If) before and after ivabradine superfusion (1 μmol/L, 7 min). Ivabradine significantly reduced pacemaker current density (pA/pF) from − 80 to − 130 mV (shown in Image).
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