Ivabradine hydrochloride

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Cat.No. 6542 - Ivabradine hydrochloride | C27H36N2O5.HCl | CAS No. 148849-67-6
Description: HCN channel blocker; inhibits If pacemaker current
Chemical Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.

Technical Data

M. Wt 505.05
Formula C27H36N2O5.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 148849-67-6
PubChem ID 3045381
InChI Key HLUKNZUABFFNQS-ZMBIFBSDSA-N
Smiles COC1=C(C=C2[C@H](CC2=C1)CN(CCCN3CCC4=CC(OC)=C(C=C4CC3=O)OC)C)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.51 100
DMSO 50.51 100

Preparing Stock Solutions

The following data is based on the product molecular weight 505.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.9 mL 19.8 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Thollon et al (1994) Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br.J.Pharmacol. 112 37 PMID: 8032660

Novella Romanelli et al (2016) HCN channel modulators: the need for selectivity. Curr.Top.Med.Chem. 16 1764 PMID: 26975509


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Citations for Ivabradine hydrochloride

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