Ivabradine hydrochloride

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Description: HCN channel blocker; inhibits If pacemaker current
Chemical Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for Ivabradine hydrochloride

Ivabradine hydrochloride is a HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.

Compound Libraries for Ivabradine hydrochloride

Ivabradine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ivabradine hydrochloride

M. Wt 505.05
Formula C27H36N2O5.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 148849-67-6
PubChem ID 3045381

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ivabradine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 50.51 100
DMSO 50.51 100

Preparing Stock Solutions for Ivabradine hydrochloride

The following data is based on the product molecular weight 505.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.9 mL 19.8 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for Ivabradine hydrochloride

References for Ivabradine hydrochloride

References are publications that support the biological activity of the product.

Thollon et al (1994) Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br.J.Pharmacol. 112 37 PMID: 8032660

Novella Romanelli et al (2016) HCN channel modulators: the need for selectivity. Curr.Top.Med.Chem. 16 1764 PMID: 26975509

If you know of a relevant reference for Ivabradine hydrochloride, please let us know.

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1 Citation for Ivabradine hydrochloride

Citations are publications that use Tocris products. Selected citations for Ivabradine hydrochloride include:

Joseph J et al (2020) BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons. J Neurophysiol 123 2449-2464 PMID: 32401131

Do you know of a great paper that uses Ivabradine hydrochloride from Tocris? Please let us know.

Reviews for Ivabradine hydrochloride

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Effect of ivabradine on pacemaker of human atrial myocytes.
By Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: primary atrial cardiomyocytes

Primary human atrial cardiomyocytes were patched to analyze mean current-voltage relationships of pacemaker current (If) before and after ivabradine superfusion (1 μmol/L, 7 min). Ivabradine significantly reduced pacemaker current density (pA/pF) from − 80 to − 130 mV (shown in Image).

review image