You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Ivabradine hydrochloride
Ivabradine hydrochloride is a HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.
Compound Libraries for Ivabradine hydrochloride
Technical Data for Ivabradine hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ivabradine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ivabradine hydrochloride
The following data is based on the product molecular weight 505.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.98 mL||9.9 mL||19.8 mL|
|5 mM||0.4 mL||1.98 mL||3.96 mL|
|10 mM||0.2 mL||0.99 mL||1.98 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
Product Datasheets for Ivabradine hydrochloride
References for Ivabradine hydrochloride
References are publications that support the biological activity of the product.
Thollon et al (1994) Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br.J.Pharmacol. 112 37 PMID: 8032660
Novella Romanelli et al (2016) HCN channel modulators: the need for selectivity. Curr.Top.Med.Chem. 16 1764 PMID: 26975509
If you know of a relevant reference for Ivabradine hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ivabradine hydrochloride, Ivabradine hydrochloride supplier, Ivabradine, HCL, HCN, blockers, blocks, bradycardic, agents, hyperpolarization, activated, current, If, inhibitors, inhibits, pacemaker, Channels, 6542, Tocris Bioscience
1 Citation for Ivabradine hydrochloride
Citations are publications that use Tocris products. Selected citations for Ivabradine hydrochloride include:
Joseph J et al (2020) BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons. J Neurophysiol 123 2449-2464 PMID: 32401131
Do you know of a great paper that uses Ivabradine hydrochloride from Tocris? Please let us know.
Reviews for Ivabradine hydrochloride
Average Rating: 5 (Based on 1 Review.)
Have you used Ivabradine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Primary human atrial cardiomyocytes were patched to analyze mean current-voltage relationships of pacemaker current (If) before and after ivabradine superfusion (1 μmol/L, 7 min). Ivabradine significantly reduced pacemaker current density (pA/pF) from − 80 to − 130 mV (shown in Image).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.