IU1

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Cat.No. 4088 - IU1 | C18H21FN2O | CAS No. 314245-33-5
Description: USP14 inhibitor
Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.

Compound Libraries

IU1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 300.37
Formula C18H21FN2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 314245-33-5
PubChem ID 675434
InChI Key JUWDSDKJBMFLHE-UHFFFAOYSA-N
Smiles O=C(CN2CCCC2)C1=C(C)N(C3=CC=C(F)C=C3)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
ethanol 15.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 300.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467 179 PMID: 20829789

Lee et al (2010) Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol.Cell.Proteomics 10 R110 PMID: 20823120


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Keywords: IU1, supplier, selective, usp14, inhibitors, inhibits, proteasome, substrate, degradation, Deubiquitinating, Enzymes, Deubiquitinating, Enzymes, Tocris Bioscience

Citations for IU1

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for IU1

Protocols

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