Potent USP14 inhibitor (IC50 = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.31||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 330.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.23 mL||151.13 mL||302.25 mL|
|0.5 mM||6.05 mL||30.23 mL||60.45 mL|
|1 mM||3.02 mL||15.11 mL||30.23 mL|
|5 mM||0.6 mL||3.02 mL||6.05 mL|
References are publications that support the biological activity of the product.
Boselli et al (2017) An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J.Biol.Chem. 292 19209 PMID: 28972160
If you know of a relevant reference for IU1-47, please let us know.
View Related Products by Product Action
Keywords: IU1-47, IU1-47 supplier, USP14, inhibitors, inhibits, potent, tau, degradation, Deubiquitinating, Enzymes, 6443, Tocris Bioscience
Citations for IU1-47
Citations are publications that use Tocris products.
Currently there are no citations for IU1-47. Do you know of a great paper that uses IU1-47 from Tocris? Please let us know.
Reviews for IU1-47
There are currently no reviews for this product. Be the first to review IU1-47 and earn rewards!
Have you used IU1-47?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells