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Potent USP14 inhibitor (IC50 = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.31||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 330.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.23 mL||151.13 mL||302.25 mL|
|0.5 mM||6.05 mL||30.23 mL||60.45 mL|
|1 mM||3.02 mL||15.11 mL||30.23 mL|
|5 mM||0.6 mL||3.02 mL||6.05 mL|
References are publications that support the biological activity of the product.
Boselli et al (2017) An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J.Biol.Chem. 292 19209 PMID: 28972160
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Keywords: IU1-47, IU1-47 supplier, USP14, inhibitors, inhibits, potent, tau, degradation, Deubiquitinating, Enzymes, 6443, Tocris Bioscience
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