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Submit ReviewISAM 140
Discontinued Product
ISAM 140 (Cat. No. 5965) has been withdrawn from sale for commercial reasons.
Description: High affinity A2B receptor antagonist
Chemical Name: 4-(2-Furanyl)-4,10-dihydro-2-methylpyrimido[1,2-a]benzimidazole-3-carboxylic acid-1-methylethyl ester
Purity: ≥98% (HPLC)
Biological Activity for ISAM 140
ISAM 140 is a high affinity A2B receptor antagonist (Ki = 3.49 nM). Exhibits >1000-fold selectivity for A2B over A1, A2A and A3 receptors.
Technical Data for ISAM 140
| M. Wt | 337.37 |
| Formula | C19H19N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 932191-62-3 |
| PubChem ID | 17198004 |
| InChI Key | NYHLRBMDXQBOIB-UHFFFAOYSA-N |
| Smiles | CC(OC(C1=C(N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)C)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ISAM 140
References for ISAM 140
References are publications that support the biological activity of the product.
El Maatougui et al (2016) Discovery of potent and highly selective A2B adenosine receptor antagonist chemotypes. J.Med.Chem. 59 1967 PMID: 26824742
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Keywords: ISAM 140, ISAM 140 supplier, ISAM140, high, affinity, adenosine, receptors, A2B, selective, Adenosine, Receptors, 5965, Tocris Bioscience
Citations for ISAM 140
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Currently there are no citations for ISAM 140.
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