ISAM 140

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Cat.No. 5965 - ISAM 140 | C19H19N3O3 | CAS No. 932191-62-3
Description: High affinity A2B receptor antagonist
Chemical Name: 4-(2-Furanyl)-4,10-dihydro-2-methylpyrimido[1,2-a]benzimidazole-3-carboxylic acid-1-methylethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity A2B receptor antagonist (Ki = 3.49 nM). Exhibits >1000-fold selectivity for A2B over A1, A2A and A3 receptors.

Technical Data

M. Wt 337.37
Formula C19H19N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 932191-62-3
PubChem ID 17198004
InChI Key NYHLRBMDXQBOIB-UHFFFAOYSA-N
Smiles CC(OC(C1=C(N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.75 20
ethanol 1.69 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

El Maatougui et al (2016) Discovery of potent and highly selective A2B adenosine receptor antagonist chemotypes. J.Med.Chem. 59 1967 PMID: 26824742


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Citations for ISAM 140

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Literature in this Area

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Pathways for ISAM 140

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