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High affinity A2B receptor antagonist (Ki = 3.49 nM). Exhibits >1000-fold selectivity for A2B over A1, A2A and A3 receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.82 mL||74.1 mL||148.21 mL|
|1 mM||2.96 mL||14.82 mL||29.64 mL|
|2 mM||1.48 mL||7.41 mL||14.82 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
References are publications that support the biological activity of the product.
El Maatougui et al (2016) Discovery of potent and highly selective A2B adenosine receptor antagonist chemotypes. J.Med.Chem. 59 1967 PMID: 26824742
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Keywords: ISAM 140, ISAM 140 supplier, ISAM140, high, affinity, adenosine, receptors, A2B, selective, Adenosine, Receptors, 5965, Tocris Bioscience
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