ISAM 140

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Cat.No. 5965 - ISAM 140 | C19H19N3O3 | CAS No. 932191-62-3
Description: High affinity A2B receptor antagonist
Chemical Name: 4-(2-Furanyl)-4,10-dihydro-2-methylpyrimido[1,2-a]benzimidazole-3-carboxylic acid-1-methylethyl ester
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for ISAM 140

ISAM 140 is a high affinity A2B receptor antagonist (Ki = 3.49 nM). Exhibits >1000-fold selectivity for A2B over A1, A2A and A3 receptors.

Technical Data for ISAM 140

M. Wt 337.37
Formula C19H19N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 932191-62-3
PubChem ID 17198004
Smiles CC(OC(C1=C(N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ISAM 140

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.75 20

Preparing Stock Solutions for ISAM 140

The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.82 mL 74.1 mL 148.21 mL
1 mM 2.96 mL 14.82 mL 29.64 mL
2 mM 1.48 mL 7.41 mL 14.82 mL
10 mM 0.3 mL 1.48 mL 2.96 mL

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References for ISAM 140

References are publications that support the biological activity of the product.

El Maatougui et al (2016) Discovery of potent and highly selective A2B adenosine receptor antagonist chemotypes. J.Med.Chem. 59 1967 PMID: 26824742

If you know of a relevant reference for ISAM 140, please let us know.

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Citations for ISAM 140

Citations are publications that use Tocris products.

Currently there are no citations for ISAM 140. Do you know of a great paper that uses ISAM 140 from Tocris? Please let us know.

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Literature in this Area

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